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4-Ethynyl-1-methyl-1H-pyrazole

CAS 39806-89-8C6H6N2Heterocyclic Building Blocks

4-Ethynyl-1-methyl-1H-pyrazole (CAS 39806-89-8) is a terminal-alkyne-bearing N-methylpyrazole building block with the molecular formula C6H6N2 and a molar mass of 106.13 g/mol. The reactive ethynyl group makes it a versatile heterocyclic synthon for medicinal and chemical research, notably in Sonogashira couplings and copper-catalysed azide-alkyne cycloaddition (click) chemistry. Tech Serve Solutions supplies it as a research-grade synthesis intermediate to laboratories and manufacturers worldwide.

Synonyms
4-Ethynyl-1-methyl-1H-pyrazole1-Methyl-4-ethynyl-1H-pyrazole4-Ethynyl-1-methylpyrazole1-Methyl-4-ethynylpyrazole
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4-Ethynyl-1-methyl-1H-pyrazole (C6H6N2) — chemical structure, CAS 39806-89-8; Chemistry, fine chemical supplied by Tech Serve Solutions
Building BlocksChemical SynthesisHeterocyclic Building BlocksPyrazoles
01 /Applications

Pharmaceutical and medicinal chemistry intermediate

Serves as a heterocyclic building block in the assembly of drug candidates and pharmaceutical intermediates. The N-methylpyrazole core is a common motif in medicinal chemistry scaffolds.

Sonogashira cross-coupling

The terminal alkyne participates in palladium- and copper-catalysed Sonogashira reactions with aryl and vinyl halides, enabling the construction of conjugated and extended molecular frameworks.

Click chemistry (CuAAC)

The ethynyl group undergoes copper-catalysed azide-alkyne cycloaddition with organic azides to form 1,2,3-triazoles, a widely used strategy in bioconjugation and library synthesis.

Heterocyclic building block for chemical synthesis

Used as a C6 synthon to introduce a methylated pyrazole unit into more complex molecules during multi-step organic synthesis and discovery programmes.

Research and laboratory reagent

Employed in academic and industrial laboratories for method development, structure-activity studies and exploratory synthesis.

02 /Properties
Molecular weight106.13
Empirical formulaC6H6N2
03 /Identifiers & registry
CAS number
39806-89-8
04 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

05 /Frequently asked questions

What is 4-Ethynyl-1-methyl-1H-pyrazole used for?

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It is used primarily as a heterocyclic building block in chemical and medicinal chemistry research. Its terminal alkyne makes it valuable for Sonogashira cross-couplings and copper-catalysed azide-alkyne cycloaddition (click) reactions to build more complex molecules and pharmaceutical intermediates.

What is the CAS number and molecular formula of 4-Ethynyl-1-methyl-1H-pyrazole?

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Its CAS number is 39806-89-8 and its molecular formula is C6H6N2, corresponding to a molecular weight of 106.13 g/mol. It is an N-methylpyrazole bearing an ethynyl (terminal alkyne) substituent at the 4-position.

What grade and purity does Tech Serve Solutions supply?

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Tech Serve Solutions supplies 4-Ethynyl-1-methyl-1H-pyrazole as a research and synthesis grade building block. We do not represent it as a USP, BP or EP pharmacopoeial grade. Exact assay and lot-specific specifications are confirmed on the certificate of analysis at the time of enquiry.

How should 4-Ethynyl-1-methyl-1H-pyrazole be handled and stored?

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Handle it as a research chemical using good laboratory practice: wear suitable gloves and eye protection, work in a fume hood and avoid release to the environment, as it carries German Water Hazard Class WGK 3 (severely hazardous to water). Store in a tightly closed container in a cool, dry, well-ventilated area away from incompatible materials, and always consult the current Safety Data Sheet before use.

How is 4-Ethynyl-1-methyl-1H-pyrazole packed, shipped and exported?

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It is packed in appropriately sealed laboratory and bulk containers with full labelling and documentation, and exported worldwide in line with applicable transport and dangerous-goods regulations. Packaging sizes and shipping arrangements are tailored to each order, with a certificate of analysis and Safety Data Sheet provided.

How do I request a sample or quote?

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Contact Tech Serve Solutions with your required quantity, intended packaging and delivery destination, and our team will respond with availability, lead time and documentation. Samples can be arranged subject to availability and regulatory requirements.

Need 4-Ethynyl-1-methyl-1H-pyrazole in a specific grade or volume?