4,4′-Difluorobiphenyl
4,4′-Difluorobiphenyl (CAS: 398-23-2) is a fluorinated organic compound with the linear formula FC6H4C6H4F and a molecular weight of 190.19 g/mol. This aryl compound serves as a valuable building block in chemical synthesis, particularly in the development of advanced materials and complex organic molecules. Its specific structure makes it useful in applications requiring tailored electronic or material properties. Tech Serve Solutions supplies this chemical with an assay of 97% for research and industrial applications.
- Synonyms
- FC6H4C6H4F

Organic Synthesis Intermediate
4,4′-Difluorobiphenyl acts as a key intermediate in the synthesis of more complex organic molecules. Its difluorinated biphenyl structure is often incorporated into liquid crystal materials or polymers to modify their physical and electronic properties.
Materials Science Research
This compound is utilised in materials science research for the development of novel polymers, organic semiconductors, and advanced functional materials. The presence of fluorine atoms can influence properties such as thermal stability, solubility, and electronic characteristics.
Pharmaceutical and Agrochemical Research
While not a direct pharmaceutical ingredient, 4,4′-Difluorobiphenyl can be employed as a building block in the research and development of new active pharmaceutical ingredients (APIs) or agrochemicals. Fluorine substitution is a common strategy to modulate the efficacy and metabolic stability of bioactive molecules.
| Molecular weight | 190.19 |
|---|---|
| Linear formula | FC6H4C6H4F |
| Assay | 97% |
| Boiling point | 254-255 °C(lit.) |
| Melting point | 88-91 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Transport (UN / ADR) | UN 3152PSN1 9 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4,4′-Difluorobiphenyl used for?
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4,4′-Difluorobiphenyl is primarily used as a building block in organic synthesis for the development of advanced materials, such as liquid crystals and polymers, and in research for novel pharmaceuticals and agrochemicals.
What is the CAS number and formula for 4,4′-Difluorobiphenyl?
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The CAS number for 4,4′-Difluorobiphenyl is 398-23-2 and its linear formula is FC6H4C6H4F.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4,4′-Difluorobiphenyl with an assay of 97%. This product is intended for research and industrial use and is not represented as USP, BP, or EP grade.
How should 4,4′-Difluorobiphenyl be handled safely?
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Based on its GHS classification, 4,4′-Difluorobiphenyl is a Warning substance. It may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (type N95 or equivalent), eyeshields, and gloves, should be used. Ensure adequate ventilation and avoid breathing dust.
Is 4,4′-Difluorobiphenyl a controlled substance?
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The provided data does not indicate that 4,4′-Difluorobiphenyl is a controlled substance.
How is 4,4′-Difluorobiphenyl packed, shipped, and exported?
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4,4′-Difluorobiphenyl is shipped according to transport regulations, with the identifier UN 3152. TSS exports chemicals globally, adhering to all relevant international shipping and customs regulations.
How can I request a sample or quote for 4,4′-Difluorobiphenyl?
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To request a sample or a quotation for 4,4′-Difluorobiphenyl, please contact the Tech Serve Solutions sales department through our website or by phone.
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