(4-(1,2,4,5-Tetrazin-3-yl)phenyl)methanamine hydrochloride
(4-(1,2,4,5-Tetrazin-3-yl)phenyl)methanamine hydrochloride (CAS: 1345866-68-3) is a amine-functionalised tetrazine reagent. Its molecular weight is 187.20 (free base basis), with the empirical formula C9H9N5 · xHCl. This compound is primarily utilised in chemical biology and synthesis for its ability to undergo inverse electron demand Diels-Alder cycloaddition reactions with strained alkenes, forming stable covalent linkages. It is a key component in bioorthogonal chemistry applications.
- IUPAC
- Benzylamino tetrazine hydrochloride,H-Tz-Bz-NH3Cl hydrochloride
- Synonyms
- 5-Tetrazin-3-yl)phenyl)methanamine hydrochloride,1345866-68-3, C9H9N5 · xHCl, Benzylamino tetrazine hydrochloride,H-Tz-Bz-NH3Cl hydrochloride
Bioorthogonal Chemistry
This tetrazine derivative is ideal for bioorthogonal reactions, enabling specific and efficient bioconjugation and biological imaging applications due to its rapid reaction kinetics with strained alkenes.
Click Chemistry
As a tetrazine reagent, it participates in inverse electron demand Diels-Alder cycloadditions, a form of click chemistry, reacting with strained alkenes like transcyclooctene to create stable covalent bonds.
Chemical Synthesis
Serves as a valuable building block in synthetic organic chemistry for the introduction of tetrazine moieties and for constructing complex molecules through cycloaddition reactions.
| Molecular weight | 187.20 (free base basis) |
|---|---|
| Empirical formula | C9H9N5 · xHCl |
| Assay | 95% |
| Storage temperature | −20°C |
| Application | Amine functionalized tetrazine for inverse electron demand Diels-Alder cycloaddition reactions. The tetrazine will react with strained alkenes such as transcyclooctene, norbornene and cyclopropene to yield a stable covalent linkage. Tetrazines have proven useful in bioorthogonal reactions for many biological imaging and bioconjugation applications. |
| Melting point | 206-225 °C (decomposition) |
Hazard statements
- H301Toxic if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P301IF SWALLOWED
- P305IF IN EYES
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25-36/37/38 |
| Safety statements (S) | 26-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (4-(1,2,4,5-Tetrazin-3-yl)phenyl)methanamine hydrochloride used for?
+
(4-(1,2,4,5-Tetrazin-3-yl)phenyl)methanamine hydrochloride is used in chemical biology and synthesis for inverse electron demand Diels-Alder cycloaddition reactions with strained alkenes, facilitating bioorthogonal chemistry applications such as biological imaging and bioconjugation.
What are the CAS number and formula for this compound?
+
The CAS number is 1345866-68-3 and the empirical formula is C9H9N5 · xHCl.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies this product with an assay of 95%. This product is not represented as USP, BP, EP or pharmacopoeia grade.
What are the primary safety hazards associated with this chemical?
+
This compound is classified as Danger (GHS06) with hazard statements H301 (Toxic if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation).
How is this chemical typically shipped and exported?
+
This chemical is classified under UN 2811, Hazard Class 6.1, Packing Group III, and is exported according to relevant dangerous goods regulations.
How can I request a sample or quote?
+
Please contact the Tech Serve Solutions sales team directly via our website or by telephone to request a sample or a quotation for (4-(1,2,4,5-Tetrazin-3-yl)phenyl)methanamine hydrochloride.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis