3-Nitrophenylboronic acid L-tartaric acid ester solution
3-Nitrophenylboronic acid L-tartaric acid ester solution (CAS: 467443-01-2, Formula: C10H8BNO8, MW: 280.98) is a chiral reagent utilized in asymmetric synthesis. Supplied as a 1.0 M solution in THF, it acts as a Lewis acid in conjunction with sodium borohydride to achieve enantioselective reduction of prochiral alkyl aryl ketones. Its specific structure and reactivity make it valuable for creating enantiomerically enriched products in chemical synthesis.
- IUPAC
- 2-(3-Nitrophenyl)-1,3,2-dioxaborolane-4R,5R-dicarboxylic acid,L-TarB-NO2
- Synonyms
- 2-(3-Nitrophenyl)-1,3,2-dioxaborolane-4R,5R-dicarboxylic acid,L-TarB-NO2
Enantioselective Ketone Reduction
This solution, when used with NaBH4, is a potent Lewis acid catalyst for the enantioselective reduction of prochiral alkyl aryl ketones. It enables the synthesis of chiral alcohols with high enantiomeric excess, crucial for pharmaceutical intermediates and fine chemical production.
Asymmetric Synthesis
As a key reagent in asymmetric synthesis, it facilitates the generation of chiral centres with controlled stereochemistry. Its application is vital in multi-step syntheses where stereochemical purity is paramount.
Chiral Catalyst Component
The L-tartaric acid ester moiety provides the chiral environment necessary for inducing asymmetry. It functions as a critical component in catalytic systems designed for stereoselective transformations.
| Molecular weight | 280.98 |
|---|---|
| Empirical formula | C10H8BNO8 |
| Density | 1.0525 g/mL at 25 °C |
| Refractive index | n20/D 1.4508 |
| Concentration | 1.0 M in THF |
| Optical activity | [α]22/D +9.0°, neat |
| Application | In conjunction with NaBH4, this Lewis acid reduces prochiral alkyl aryl ketones with excellent enantioselectivity.1,2 |
Hazard statements
- H225Highly flammable liquid and vapour
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P281Use personal protective equipment as required
- P305IF IN EYES
| Flash point | -17 °C / 1.4 °F |
|---|---|
| Transport (UN / ADR) | UN 2056 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-19-36/37-40 |
| Safety statements (S) | 16-26-36/37 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Nitrophenylboronic acid L-tartaric acid ester solution used for?
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It is used as a Lewis acid catalyst, in conjunction with NaBH4, for the enantioselective reduction of prochiral alkyl aryl ketones, primarily in asymmetric synthesis.
What are the CAS number and formula for this product?
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The CAS number is 467443-01-2 and the empirical formula (Hill notation) is C10H8BNO8.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product as a 1.0 M solution in THF. The exact assay and purity are detailed in the product specifications. We do not represent this product as USP, BP, or EP grade.
How should 3-Nitrophenylboronic acid L-tartaric acid ester solution be handled safely?
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This solution is highly flammable (Flash Point: -17 °C / 1.4 °F) and may form explosive peroxides. Handle in a well-ventilated area, away from ignition sources. It can cause serious eye irritation and respiratory irritation. Wear appropriate personal protective equipment, including gloves, eye protection, and respiratory protection. Refer to the Safety Data Sheet for full details.
How is this chemical packed, shipped, and exported?
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This product is classified under UN 2056, Packing Group II, indicating specific requirements for packaging, labelling, and transportation. Tech Serve Solutions, as an experienced global exporter, ensures compliance with all relevant shipping regulations for hazardous materials.
How can I request a sample or a quote?
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Please contact our sales team directly through the website or by phone to request a sample or a quotation for 3-Nitrophenylboronic acid L-tartaric acid ester solution.
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