3-Fluorobenzoyl chloride
3-Fluorobenzoyl chloride (CAS: 1711-07-5) is a chemical compound with the molecular formula C7H4ClFO and a molecular weight of 158.56 g/mol. As an acid halide and a fluorinated building block, it serves as a key intermediate in organic synthesis. Its primary applications are in the preparation of pharmaceuticals, agrochemicals, and other fine chemicals requiring the introduction of a 3-fluorobenzoyl moiety into target molecules.
Radiosynthesis of Pharmaceutical Intermediates
3-Fluorobenzoyl chloride has been utilised in the radiosynthesis of compounds such as 4-[18F]fluoro-N-[2-[1-(2-methoxyphenyl)-1-piperazinyl]ethyl-N-2-pyridinyl-benzamide, contributing to the development of novel imaging agents.
Synthesis of Heterocyclic Compounds
This reagent is employed in the one-pot synthesis of N-(1,3-diphenyl-1H-pyrazol-5-yl)amides, offering an efficient route to complex heterocyclic structures with potential biological activity.
Analytical Chemistry Applications
In analytical methods, 3-Fluorobenzoyl chloride has been used as a derivatising agent in techniques like hollow fibre liquid-phase microextraction coupled with HPLC-UV for the determination of pharmaceutical compounds in biological samples.
| Molecular weight | 158.56 |
|---|---|
| Linear formula | FC6H4COCl |
| Assay | 98% |
| Boiling point | 189 °C(lit.) |
| Density | 1.304 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.529(lit.) |
| Application | 3-Fluorobenzoyl chloride was used in synthesis of 4-[18F]fluoro-N-[2-[1-(2-methoxyphenyl)-1-piperazinyl]ethyl-N-2-pyridinyl-benzamide by radiosynthesis1. It was also used as reagent in one-pot synthesis of N-(1,3-diphenyl-1H-pyrazol-5-yl)amides2. It was used in three phase hollow fiber liquid-phase microextraction with in situ derivatization method coupled with HPLC-UV for the determination of metformin hydrochloride in biological fluids3. |
| Melting point | −30 °C(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 82 °C / 179.6 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34-37 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Fluorobenzoyl chloride used for?
+
3-Fluorobenzoyl chloride is primarily used as a building block and intermediate in organic synthesis, particularly for the preparation of pharmaceuticals, agrochemicals, and other fine chemicals.
What is the CAS number and molecular formula for 3-Fluorobenzoyl chloride?
+
The CAS number for 3-Fluorobenzoyl chloride is 1711-07-5, and its linear molecular formula is C7H4ClFO.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies 3-Fluorobenzoyl chloride with a minimum assay of 98%. We do not represent this product as USP, BP, or EP grade.
How should 3-Fluorobenzoyl chloride be handled safely?
+
3-Fluorobenzoyl chloride is a corrosive substance that causes severe skin burns and eye damage. Handling requires appropriate personal protective equipment, including faceshields, gloves, goggles, and suitable respiratory protection. Refer to the safety data sheet for detailed handling procedures.
Is 3-Fluorobenzoyl chloride available for export?
+
Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 3-Fluorobenzoyl chloride.
How can I request a sample or quote for 3-Fluorobenzoyl chloride?
+
Please contact our sales department via the website or by phone to request a sample or a quotation for 3-Fluorobenzoyl chloride.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis