3-Fluoro-4-formylphenylboronic acid
3-Fluoro-4-formylphenylboronic acid (CAS 248270-25-9, C7H6BFO3) is an organoboron compound with a molecular weight of 167.93 g/mol. This aromatic boronic acid features both a fluorine atom and a formyl group on the phenyl ring, making it a valuable intermediate in organic synthesis. It serves as a key building block in the preparation of more complex molecules, particularly in pharmaceutical research and development.
- IUPAC
- 3-Fluoro-4-formylbenzeneboronic acid
- Synonyms
- 3-Fluoro-4-formylbenzeneboronic acid
Suzuki-Miyaura Cross-Coupling Reactions
This compound is utilised as a reactant in the preparation of MIDA boronates, which are crucial intermediates for Suzuki-Miyaura cross-coupling reactions. This enables the efficient formation of carbon-carbon bonds in complex organic structures.
Synthesis of Kinase Inhibitors
It serves as a precursor in the synthesis of pyrazolopyrimidinamine derivatives. These derivatives have shown potential as inhibitors of tyrosine and phosphoinositide kinases, relevant in medicinal chemistry research.
Organic Building Block
As a disubstituted aryl boronic acid, 3-Fluoro-4-formylphenylboronic acid functions as a versatile organic building block. Its unique functional groups allow for diverse synthetic transformations in the development of novel compounds.
| Molecular weight | 167.93 |
|---|---|
| Empirical formula | C7H6BFO3 |
| Application | Reactant for:• Preparation of MIDA boronates for Suzuki-Miyaura cross-coupling reactions1• Preparation of pyrazolopyrimidinamine derivatives as tyrosine and phosphinositide kinase inhibitors2 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Fluoro-4-formylphenylboronic acid used for?
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3-Fluoro-4-formylphenylboronic acid is used as a reactant in the preparation of MIDA boronates for Suzuki-Miyaura cross-coupling reactions and in the synthesis of pyrazolopyrimidinamine derivatives with kinase inhibitory activity. It is a valuable organic building block.
What are the CAS number and formula for 3-Fluoro-4-formylphenylboronic acid?
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The CAS number is 248270-25-9 and the empirical formula (Hill notation) is C7H6BFO3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product as a research-grade chemical. The exact purity is not specified beyond general laboratory reagent standards, and it is not represented as USP, BP, or EP grade.
How should 3-Fluoro-4-formylphenylboronic acid be handled safely?
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Based on its GHS classification, 3-Fluoro-4-formylphenylboronic acid is a Warning substance, classified with H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Appropriate personal protective equipment, including a dust mask (N95 type), eyeshields, and gloves, should be worn. Handle in a well-ventilated area or fume hood.
Is this product a controlled substance?
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The provided data does not indicate that 3-Fluoro-4-formylphenylboronic acid is a controlled substance.
How is this chemical packed, shipped, and exported?
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Tech Serve Solutions packs, ships, and exports chemicals in compliance with all relevant international regulations. Specific packaging details are available upon request.
How can I request a sample or quote?
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To request a sample or a quotation for 3-Fluoro-4-formylphenylboronic acid, please contact the Tech Serve Solutions sales department through our official website or by telephone.
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