3-Fluoro-2-methylphenyl isocyanate
3-Fluoro-2-methylphenyl isocyanate (CAS 60221-81-0) is a fluorinated aromatic building block with the molecular formula C8H6FNO. This versatile intermediate, weighing 151.14 g/mol, is valuable in organic synthesis, particularly for introducing fluorinated aryl moieties into complex molecules. It is commonly employed in the development of pharmaceuticals, agrochemicals, and advanced materials, leveraging its unique reactivity for targeted chemical transformations.
Pharmaceutical Intermediate
Utilised in the synthesis of novel drug candidates and active pharmaceutical ingredients (APIs). Its fluorinated structure can enhance metabolic stability and lipophilicity of drug molecules.
Agrochemical Synthesis
Serves as a key building block in the development of advanced pesticides, herbicides, and fungicides. Fluorine substitution can often improve the efficacy and environmental profile of agrochemicals.
Materials Science
Incorporated into the synthesis of specialty polymers and functional materials where fluorination imparts desirable properties such as thermal stability and chemical resistance.
Organic Synthesis Reagent
A reactive isocyanate group allows for facile derivatisation, making it a useful reagent for creating ureas, carbamates, and other functional groups in complex organic molecules.
| Molecular weight | 151.14 |
|---|---|
| Empirical formula | C8H6FNO |
| Assay | 97% |
| Density | 1.164 g/mL at 25 °C |
| Refractive index | n20/D 1.518 |
| Storage temperature | 2-8°C |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 71 °C / 159.8 °F |
| Transport (UN / ADR) | UN 3334 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Fluoro-2-methylphenyl isocyanate used for?
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3-Fluoro-2-methylphenyl isocyanate is primarily used as a building block in organic synthesis for the development of pharmaceuticals, agrochemicals, and advanced materials.
What are the CAS number and molecular formula?
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The CAS number for 3-Fluoro-2-methylphenyl isocyanate is 60221-81-0, and its molecular formula is C8H6FNO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-Fluoro-2-methylphenyl isocyanate with an assay of 97%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 3-Fluoro-2-methylphenyl isocyanate be handled safely?
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This compound is harmful if swallowed, in contact with skin, or if inhaled, and causes skin and serious eye irritation, as well as respiratory irritation. Appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, must be used. Handle in a well-ventilated area and store under refrigeration (2-8°C).
How is this chemical packed and shipped?
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Tech Serve Solutions, as a specialist global supplier and exporter, ensures appropriate packing and adherence to all shipping regulations for 3-Fluoro-2-methylphenyl isocyanate.
How can I request a sample or quote for 3-Fluoro-2-methylphenyl isocyanate?
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Please contact our sales team via the website or your designated account manager to request a sample or obtain a quotation for 3-Fluoro-2-methylphenyl isocyanate.
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