[3-(Ethoxycarbonyl)propyl]triphenylphosphonium bromide
[3-(Ethoxycarbonyl)propyl]triphenylphosphonium bromide (CAS: 50479-11-3) is a Wittig reagent with the molecular formula C22H24BrO2P. It is a valuable synthetic intermediate used in organic chemistry, particularly for C-C bond formation and olefination reactions. Available from Tech Serve Solutions, this compound serves as a key reactant in various chemical syntheses, enabling the creation of complex molecules.
- IUPAC
- NSC 269919
![[3-(Ethoxycarbonyl)propyl]triphenylphosphonium bromide (C2H5O2C(CH2)3P(C6H5)3Br) — chemical structure, CAS 50479-11-3; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F50479-11-3.png&w=3840&q=75)
Wittig Reagent for Olefination
This phosphonium salt is employed in Wittig reactions to synthesize olefins. It acts as a precursor to ylides, which react with carbonyl compounds to form carbon-carbon double bonds.
Synthesis of Ezetimibe
It is utilised as a reactant in the asymmetric synthesis of Ezetimibe, an important antihypercholesterolemic agent, showcasing its application in pharmaceutical intermediate production.
General C-C Bond Formation
As a versatile synthetic reagent, it facilitates the formation of new carbon-carbon bonds, a fundamental transformation in organic synthesis and medicinal chemistry.
| Molecular weight | 457.34 |
|---|---|
| Linear formula | C2H5O2C(CH2)3P(C6H5)3Br |
| Assay | 97% |
| Application | Reactant for:• Asymmetric synthesis of antihypercholesterolemic ezetimibe via Wittig reaction1• Wittig reactions2 |
| Melting point | 165-167 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is [3-(Ethoxycarbonyl)propyl]triphenylphosphonium bromide used for?
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[3-(Ethoxycarbonyl)propyl]triphenylphosphonium bromide is primarily used as a Wittig reagent for olefination reactions and in the synthesis of pharmaceutical intermediates like Ezetimibe.
What is the CAS number and chemical formula?
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The CAS number is 50479-11-3 and the chemical formula is C22H24BrO2P.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies [3-(Ethoxycarbonyl)propyl]triphenylphosphonium bromide with an assay of 97%. This product is typically considered for research and laboratory use and is not supplied as USP, BP, or EP grade.
How should [3-(Ethoxycarbonyl)propyl]triphenylphosphonium bromide be handled safely?
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Handling requires caution. It is a Warning substance, causing skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Use a dust mask type N95, eyeshields, and gloves. Ensure good ventilation.
Is this chemical a controlled substance?
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There is no indication in the provided data that [3-(Ethoxycarbonyl)propyl]triphenylphosphonium bromide is a controlled substance.
How is this chemical packed and shipped?
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Products are carefully packed according to international shipping regulations. Tech Serve Solutions has extensive experience in exporting fine chemicals globally.
How can I request a quote or sample?
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Please contact our sales team through the website or by phone to request a quotation or a sample of [3-(Ethoxycarbonyl)propyl]triphenylphosphonium bromide.
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