3-(Diphenylphosphino)propionic acid
3-(Diphenylphosphino)propionic acid (CAS: 2848-01-3), with the molecular formula C15H15O2P and a molecular weight of 258.25 g/mol, is a valuable organophosphorus compound. It functions as a key reactant in various sophisticated chemical syntheses. Its applications span organocatalysis, the transformation of azides, and the preparation of transition metal catalysts, making it a versatile reagent for advanced chemical research and development.
- IUPAC
- (2-Carboxyethyl)diphenylphosphine,4,4-Diphenyl-4-phosphabutanoic acid
- Synonyms
- (2-Carboxyethyl)diphenylphosphine4,4-Diphenyl-4-phosphabutanoic acid
Organocatalytic Asymmetric Aziridination
This compound serves as a reactant in the organocatalytic asymmetric aziridination of imines and diazo compounds. This application is crucial for the stereoselective synthesis of complex nitrogen-containing heterocycles.
Phosphine-Mediated Azide Transformations
It is employed in phosphine-mediated reactions for the conversion of azides into diazo compounds. This process is essential for generating reactive intermediates used in further synthetic transformations.
Preparation of Rhodium Catalysts
3-(Diphenylphosphino)propionic acid is utilised in the preparation of rhodium catalysts. These catalysts are particularly important for applications in hydroformylation reactions, a key industrial process.
Synthesis of Mitsunobu Reagents
The compound is a precursor for synthesising reagents employed in the Mitsunobu reaction. This reaction is widely recognised for its utility in achieving stereochemical inversion during alcohol functionalisation.
| Molecular weight | 258.25 |
|---|---|
| Empirical formula | C15H15O2P |
| Assay | 97% |
| Application | Reactant for:• Organocatalytic asymmetric aziridination of imines and diazo compounds1• Phosphine-mediated conversion of azides into diazo compounds2• Preparation of rhodium catalysts for hydroformylation3• Synthesis of reagents for the Mitsunobu reaction4 |
| Melting point | 130-134 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-(Diphenylphosphino)propionic acid used for?
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3-(Diphenylphosphino)propionic acid is used as a reactant in organocatalytic asymmetric aziridination of imines and diazo compounds, phosphine-mediated conversion of azides into diazo compounds, preparation of rhodium catalysts for hydroformylation, and the synthesis of reagents for the Mitsunobu reaction.
What is the CAS number and molecular formula for 3-(Diphenylphosphino)propionic acid?
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The CAS number is 2848-01-3 and the molecular formula is C15H15O2P.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-(Diphenylphosphino)propionic acid with an assay of 97%. We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should 3-(Diphenylphosphino)propionic acid be handled?
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3-(Diphenylphosphino)propionic acid is a Warning substance that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Handle with appropriate personal protective equipment, ensuring good ventilation, and avoid contact with skin, eyes, and clothing. Refer to the Safety Data Sheet for full details.
Is 3-(Diphenylphosphino)propionic acid a controlled substance?
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The provided data does not indicate that 3-(Diphenylphosphino)propionic acid is a controlled substance.
How is 3-(Diphenylphosphino)propionic acid packed and shipped?
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Tech Serve Solutions exports fine chemicals globally. Specific packing and shipping details for 3-(Diphenylphosphino)propionic acid will be provided upon request, adhering to all relevant regulations.
How can I request a sample or quote for 3-(Diphenylphosphino)propionic acid?
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To request a sample or quote for 3-(Diphenylphosphino)propionic acid, please contact our sales department through the website or by phone, providing your specific requirements.
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