4,4,5,5-Tetramethyl-1,3,2-dioxaphospholane 2-oxide
4,4,5,5-Tetramethyl-1,3,2-dioxaphospholane 2-oxide (CAS: 16352-18-4; C6H13O3P; MW: 164.14) is a phosphine compound and air-stable preligand. It is a key reagent employed in palladium-catalyzed cross-coupling reactions, particularly for Kumada-type couplings. This compound is supplied by Tech Serve Solutions with a minimum assay of 95%, suitable for research and synthetic applications.
- IUPAC
- 2-Oxo-4,4,5,5-tetramethyl-1,3,2-dioxaphospholane,4,4,5,5-Tetramethyl-1,3,2-dioxaphospholan-2-ol,HASPO-1,Phosphonic acid pinacol ester,Pinacol phosphonate
- Synonyms
- 5-Tetramethyl-1,3,2-dioxaphospholane 2-oxide2-Oxo-4,4,5,5-tetramethyl-1,3,2-dioxaphospholane4,4,5,5-Tetramethyl-1,3,2-dioxaphospholan-2-olHASPO-1Phosphonic acid pinacol esterPinacol phosphonate
Palladium-Catalyzed Cross-Coupling Reactions
This compound serves as an air-stable preligand in palladium-catalyzed cross-coupling reactions. Its utility is particularly noted in facilitating Kumada-type couplings, enabling efficient formation of carbon-carbon bonds.
Chemical Synthesis
As a versatile organophosphorus reagent, it finds application in various synthetic methodologies within organic and inorganic chemistry. Its structure allows for controlled introduction of phosphorus moieties into complex molecules.
Catalysis Research
Its role as a preligand makes it a valuable tool for researchers developing new catalytic systems and exploring novel reaction pathways, especially those involving transition metal catalysis.
| Molecular weight | 164.14 |
|---|---|
| Empirical formula | C6H13O3P |
| Assay | 95% |
| Application | Air-stable preligand for Pd-catalyzed Kumada-type cross-couplings.1 |
| Melting point | 99-106 °C |
Hazard statements
- H312Harmful in contact with skin
- H319Causes serious eye irritation
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 21-36 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4,4,5,5-Tetramethyl-1,3,2-dioxaphospholane 2-oxide used for?
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It is primarily used as an air-stable preligand in palladium-catalyzed Kumada-type cross-coupling reactions and for general chemical synthesis.
What is the CAS number and formula for 4,4,5,5-Tetramethyl-1,3,2-dioxaphospholane 2-oxide?
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The CAS number is 16352-18-4, and the empirical formula is C6H13O3P.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4,4,5,5-Tetramethyl-1,3,2-dioxaphospholane 2-oxide with a minimum assay of 95%. This product is not supplied to any pharmacopoeia standards (e.g., USP, EP, BP).
How should 4,4,5,5-Tetramethyl-1,3,2-dioxaphospholane 2-oxide be handled?
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Handle with appropriate personal protective equipment including a dust mask type N95 (US), eyeshields, and gloves. Avoid contact with skin and eyes. This compound is classified as harmful if swallowed or in contact with skin and causes serious eye irritation.
Is this chemical a controlled substance?
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Based on the provided data, there is no indication that 4,4,5,5-Tetramethyl-1,3,2-dioxaphospholane 2-oxide is a controlled substance.
How is this chemical exported and shipped?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals. Details regarding specific shipping and export procedures for 4,4,5,5-Tetramethyl-1,3,2-dioxaphospholane 2-oxide can be provided upon request.
How can I request a sample or quote?
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To request a sample or a quote for 4,4,5,5-Tetramethyl-1,3,2-dioxaphospholane 2-oxide, please contact the Tech Serve Solutions sales team via our website or direct inquiry channels.
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