4-Iodobenzoyl chloride
4-Iodobenzoyl chloride (CAS: 1711-02-0) is an organic acid halide with the molecular formula IC6H4COCl and a molar mass of 266.46 g/mol. This compound serves as a versatile building block in organic synthesis. Its applications include the modification of polymers, the preparation of potential pharmaceutical agents targeting dopamine receptors, and the synthesis of advanced materials like rotaxanes and pyrroles.
Polymer Modification
4-Iodobenzoyl chloride has been utilised to modify poly(allylamine), rendering the polymer X-ray visible. This application is valuable in materials science for creating radiopaque polymers.
Dopamine D4 Antagonist Preparation
It is employed in the synthesis of N-(1-benzylpyrrolidin-3-yl)arylbenzamide derivatives. These compounds have been investigated for their potential as human dopamine D4 receptor antagonists.
Rotaxane Synthesis
The compound serves as a monomer for the preparation of [2] rotaxane structures, which are essential precursors for the synthesis of poly[2] rotaxanes.
Pyrrole Synthesis
4-Iodobenzoyl chloride participates in palladium-catalysed synthesis of pyrroles from imines and acetylenes via isocyanide mediation, a key reaction in heterocyclic chemistry.
| Molecular weight | 266.46 |
|---|---|
| Linear formula | IC6H4COCl |
| Assay | 97% |
| Boiling point | 120-121 °C/1 mmHg(lit.) |
| Application | 4-Iodobenzoyl chloride has been used in:• modification of poly(allylamine), to make the polymer x-ray visible1• preparation of series of N-(1-benzylpyrrolidin-3-yl)arylbenzamides, potential human dopamine D4 antagonists2• preparation of [2] rotaxane monomer, for poly [2] rotaxane synthesis3• synthesis of pyrroles from imines and acetylenes mediated by isocyanides versus palladium catalysis4 |
| Melting point | 63-65 °C(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Iodobenzoyl chloride used for?
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4-Iodobenzoyl chloride is a versatile building block used in organic synthesis for applications such as polymer modification, the preparation of potential dopamine D4 antagonists, the synthesis of rotaxanes, and the creation of pyrroles.
What is the CAS number and chemical formula for 4-Iodobenzoyl chloride?
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The CAS number is 1711-02-0 and the linear chemical formula is IC6H4COCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Iodobenzoyl chloride with an assay of 97%. We do not represent this product as USP, BP, or EP grade; it is suitable for research and technical applications.
How should 4-Iodobenzoyl chloride be handled safely?
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4-Iodobenzoyl chloride is classified as Danger (GHS05) and causes severe skin burns and eye damage (H314). Appropriate personal protective equipment, including eyeshields, face shields, gloves, and suitable respiratory protection, must be used. Handle only in a well-ventilated area or fume hood.
How is 4-Iodobenzoyl chloride packed, shipped, and exported?
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4-Iodobenzoyl chloride is carefully packed according to international regulations for hazardous materials. We are experienced in exporting chemicals globally, ensuring compliance with all relevant shipping and customs requirements.
How can I request a sample or quote for 4-Iodobenzoyl chloride?
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To request a sample or a quote for 4-Iodobenzoyl chloride, please contact our sales team through the website or by calling our direct line. Please provide your contact details and the quantity required.
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