(3-(Dimethylamino)propyl)triphenylphosphonium bromide
(3-(Dimethylamino)propyl)triphenylphosphonium bromide (CAS: 18355-96-9) is a phosphonium salt with the molecular formula (CH3)2NCH2CH2CH2P(C6H5)3(Br) and a molecular weight of 428.34 g/mol. This compound serves as a versatile reagent in organic synthesis, primarily recognised for its utility in C-C bond formation and olefination reactions, including the Wittig reaction.
Preparation of Topoisomerase I-Targeting Antitumor Agents
This compound is employed as a key reactant in the synthesis of novel antitumor agents that target topoisomerase I. Its chemical structure facilitates the introduction of specific functionalities required for biological activity.
Synthesis of Complex Organic Molecules
It acts as a reactant in the multi-step synthesis of complex natural products, such as the C15-C21 stereopentad of discodermolide. This involves processes including cleavage, isomerization, and selective protection steps.
Development of Sodium Channel Blockers
The phosphonium salt is utilised in the preparation of diphenylamine-based sodium channel blockers. These compounds have shown efficacy, for instance, against the hNav1.2 subtype.
Wittig Reaction Reagent
It serves as a reactant in the Wittig reaction, specifically demonstrated in its reaction with benzaldehyde. This application highlights its role in olefination chemistry for creating carbon-carbon double bonds.
| Molecular weight | 428.34 |
|---|---|
| Linear formula | (CH3)2NCH2CH2CH2P(C6H5)3(Br) |
| Assay | 98% |
| Application | Reactant for preparation of:• Topoisomerase I-targeting antitumor agents1• C15-C21 stereopentad of discodermolide via cleavage of aminoglycosides, double-bond isomerization, and selective hydroxyl group protection2• Diphenyl amine based sodium channel blockers, effective against hNav1.23• Reactant for Wittig reaction with benzaldehyde4 |
| Melting point | 193-196 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (3-(Dimethylamino)propyl)triphenylphosphonium bromide used for?
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(3-(Dimethylamino)propyl)triphenylphosphonium bromide is used as a reactant in organic synthesis, particularly for C-C bond formation, olefination reactions like the Wittig reaction, and in the preparation of antitumor agents, complex organic molecules, and sodium channel blockers.
What is the CAS number and formula for this compound?
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The CAS number is 18355-96-9, and the linear formula is (CH3)2NCH2CH2CH2P(C6H5)3(Br).
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with an assay of 98%. We provide this as a research or technical grade material and do not represent it as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety and handling considerations?
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This compound is classified with GHS07 symbol and carries a Warning signal word. It causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, should be used. Handle in a well-ventilated area.
Is this chemical packed and shipped internationally by TSS?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals and laboratory reagents, including (3-(Dimethylamino)propyl)triphenylphosphonium bromide.
How can I request a sample or quote?
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To request a sample or a quote for (3-(Dimethylamino)propyl)triphenylphosphonium bromide, please contact our sales team through the website or by phone.
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