3-[Bis(trimethylsilyl)amino]phenylmagnesium chloride solution
3- [Bis(trimethylsilyl)amino]phenylmagnesium chloride solution (CAS: 174484-84-5), with the linear formula [(CH<sub>3</sub>)<sub>3</sub>Si]<sub>2</sub>NC<sub>6</sub>H<sub>4</sub>MgCl and molecular weight 296.24, is an organometallic reagent. Supplied as a 1.0 M solution in THF, this aryl Grignard reagent is highly reactive. It is primarily utilised in organic synthesis for introducing the 3- [bis(trimethylsilyl)amino]phenyl group into target molecules, finding application in the preparation of complex organic compounds and pharmaceutical intermediates.
![3-[Bis(trimethylsilyl)amino]phenylmagnesium chloride solution ([(CH3)3Si]2NC6H4MgCl) — chemical structure, CAS 174484-84-5; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F174484-84-5.png&w=3840&q=75)
Organometallic Synthesis
This compound serves as a valuable nucleophile in organic synthesis, enabling the formation of new carbon-carbon bonds. Its aryl Grignard nature allows for versatile transformations.
Pharmaceutical Intermediate Preparation
It is employed in the multi-step synthesis of complex organic molecules, potentially including active pharmaceutical ingredients (APIs). Its specific functionalisation is key in building sophisticated molecular architectures.
Research and Development
As a specialised reagent, it is used in academic and industrial research laboratories for exploring novel synthetic pathways and developing new chemical entities.
| Molecular weight | 296.24 |
|---|---|
| Linear formula | [(CH3)3Si]2NC6H4MgCl |
| Boiling point | 67 °C |
| Density | 0.954 g/mL at 25 °C |
| Concentration | 1.0 M in THF |
Hazard statements
- H225Highly flammable liquid and vapour
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | -12 °C / 10.4 °F |
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-14-19-34-37-40 |
| Safety statements (S) | 16-26-36/37/39-45 |
| Supplemental hazards | May form explosive peroxides., Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-[Bis(trimethylsilyl)amino]phenylmagnesium chloride solution used for?
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This solution is primarily used as a reagent in organic synthesis to introduce the 3- [bis(trimethylsilyl)amino]phenyl moiety into molecules, finding application in the preparation of complex organic compounds and pharmaceutical intermediates.
What is the CAS number and formula for 3-[Bis(trimethylsilyl)amino]phenylmagnesium chloride solution?
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The CAS number is 174484-84-5, and the linear formula is [(CH<sub>3</sub>)<sub>3</sub>Si]<sub>2</sub>NC<sub>6</sub>H<sub>4</sub>MgCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product as a 1.0 M solution in THF. We do not specify a particular purity assay beyond its concentration, and it is not represented as USP/BP/EP grade.
What are the key safety concerns when handling this product?
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This product is flammable (H225) and corrosive (H314), causing severe skin burns and eye damage. It may form explosive peroxides and reacts violently with water. Appropriate personal protective equipment, including gloves, eye protection, and respiratory protection, is essential. Handle under inert atmosphere.
How is 3-[Bis(trimethylsilyl)amino]phenylmagnesium chloride solution packed, shipped, and exported?
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As a specialist global supplier, Tech Serve Solutions ensures appropriate packaging for the safe transport of this hazardous chemical, adhering to international shipping regulations for flammable and corrosive materials. We export worldwide.
How can I request a sample or quote for this chemical?
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To request a sample or a detailed quotation, please contact our sales department through the website or call us directly. Please provide your specific requirements and shipping details.
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