3,5-Bis(trifluoromethyl)hydrocinnamic acid
3,5-Bis(trifluoromethyl)hydrocinnamic acid (CAS 181772-16-7) is a specialised organic building block featuring a propionic acid chain substituted with two trifluoromethyl groups on the phenyl ring. This compound, with a molecular weight of 286.17 g/mol, serves as a key intermediate in the synthesis of novel amides. Its chemical structure makes it valuable for researchers and manufacturers in the pharmaceutical and chemical industries seeking to develop new biologically active compounds.
- IUPAC
- 3-[3,5-Bis(trifluoromethyl)phenyl]propionic acid
- Synonyms
- (CF3)2C6H3CH2CH2CO2H3-[3,5-Bis(trifluoromethyl)phenyl]propionic acid
Synthesis of Biologically Active Amides
This compound is specifically utilised for the preparation of novel amides, contributing to the development of new pharmaceutical candidates. Its unique trifluoromethyl substitution pattern can influence the pharmacokinetic and pharmacodynamic properties of the resulting molecules.
Organic Synthesis Intermediate
As a carboxylic acid with potent electron-withdrawing trifluoromethyl groups, it acts as a versatile intermediate in various organic synthesis pathways. It is suitable for reactions requiring electrophilic aromatic substitution or nucleophilic acyl substitution.
Research and Development
Utilised in academic and industrial R&D settings for exploring new chemical entities and reaction methodologies. Its specific structural features are of interest for medicinal chemistry and materials science applications.
| Molecular weight | 286.17 |
|---|---|
| Linear formula | (CF3)2C6H3CH2CH2CO2H |
| Assay | 97% |
| Application | Used to prepare novel biologically active amides.1 |
| Melting point | 68-73 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3,5-Bis(trifluoromethyl)hydrocinnamic acid used for?
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It is primarily used as an intermediate in the synthesis of novel biologically active amides and in general organic synthesis research.
What are the CAS number and chemical formula for this compound?
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The CAS number is 181772-16-7, and its linear formula is (CF3)2C6H3CH2CH2CO2H.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product with an assay of 97%. We do not represent this product as USP, BP, or EP grade.
What are the safety and handling precautions for 3,5-Bis(trifluoromethyl)hydrocinnamic acid?
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This compound is classified as a Warning, with hazards including skin irritation (H315), eye irritation (H319), and respiratory irritation (H335). Recommended personal protective equipment includes a dust mask type N95, eyeshields, and gloves. Ensure adequate ventilation and avoid dust formation.
How is this chemical exported or shipped?
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Tech Serve Solutions is a global supplier and exporter of fine chemicals, pharmaceutical intermediates, and laboratory reagents. Specific shipping and export details can be provided upon request.
How can I request a sample or quote for 3,5-Bis(trifluoromethyl)hydrocinnamic acid?
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Please contact our sales department directly through the website to request a sample or a formal quotation for this product.
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