2-Methyl-5-nitroindole
2-Methyl-5-nitroindole (CAS: 7570-47-0, C9H8N2O2) is a heterocyclic organic compound supplied by Tech Serve Solutions. With a molecular weight of 176.17 g/mol, this indole derivative serves as a crucial building block in chemical synthesis. Its primary utility lies as a reactant in the preparation of various complex organic molecules, including pharmaceutical intermediates and biologically active compounds.
- IUPAC
- NSC 131898
Synthesis of β-Substituted Indoles
This compound is a valuable precursor for the synthesis of diverse indole derivatives, such as β-cyanoindoles and methanoindoles, which are core structures in medicinal chemistry.
Development of Kinase Inhibitors
It is utilised in the research and development of potent inhibitors targeting protein kinase C theta (PKCθ), an important target in immunology and cancer research.
Creation of Receptor Antagonists
2-Methyl-5-nitroindole serves as a reactant in the preparation of peptide-mimetic antagonists for protease-activated receptor-1 (PAR-1), relevant for thrombosis and inflammation studies.
Inhibitors of Cellular Pathways
The compound is employed in the synthesis of inhibitors for key biological pathways, including tubulin polymerization and cytosolic phospholipase A2α (cPLA2α), impacting cell division and inflammatory responses.
Ligands for Serotonin Receptors
It is a reactant in the synthesis of novel ligands targeting the Serotonin 5-HT6 Receptor, which is of interest for the treatment of neurological disorders.
| Molecular weight | 176.17 |
|---|---|
| Empirical formula | C9H8N2O2 |
| Assay | 97% |
| Application | Reactant for preparation of:β• Cyanoindoles1• Methanoindoles2• Protein kinase C theta (PKCθ) inhibitors3• Tubulin polymerization inhibitors4• Peptide-mimetic protease-activated receptor-1 (PAR-1) antagonists5• Cytosolic phospholipase A2α6• Cyclooxygenase (COX) inhibitors7• Serotonin 5-HT6 Receptor Ligands8• Heterocyclic β-substituted alanine derivatives |
| Melting point | 172-176 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Methyl-5-nitroindole used for?
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2-Methyl-5-nitroindole (CAS: 7570-47-0) is primarily used as a reactant in chemical synthesis for preparing various indole derivatives, including β-cyanoindoles, methanoindoles, protein kinase C theta (PKCθ) inhibitors, and other biologically active compounds.
What are the CAS number and molecular formula for 2-Methyl-5-nitroindole?
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The CAS number for 2-Methyl-5-nitroindole is 7570-47-0, and its molecular formula is C9H8N2O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Methyl-5-nitroindole with an assay of 97%. This product is intended for laboratory and research use, and is not supplied as USP, BP, or EP grade.
How should 2-Methyl-5-nitroindole be handled safely?
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According to GHS, 2-Methyl-5-nitroindole is classified with Warning signal word and hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). It is recommended to wear a dust mask type N95, eyeshields, and gloves, and to avoid breathing dust. In case of eye contact, rinse cautiously with water for several minutes and remove contact lenses if present and easy to do. Continue rinsing.
How is 2-Methyl-5-nitroindole packed and shipped?
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2-Methyl-5-nitroindole is carefully packed to ensure safe handling and is exported globally by Tech Serve Solutions. Specific packaging details are available upon request.
How can I request a sample or quote for 2-Methyl-5-nitroindole?
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To request a sample or a quote for 2-Methyl-5-nitroindole, please contact our sales department through the website or by calling us directly.
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