(2-Hydroxypropyl)-β-cyclodextrin
(2-Hydroxypropyl)-β-cyclodextrin, CAS 128446-35-5, has an average molecular weight of approximately 1,460 g/mol and an extent of labeling of 0.8 molar substitution. This versatile cyclodextrin derivative is primarily used to enhance the solubility of lipophilic compounds through complexation within its non-polar cavity. It is suitable for cell culture applications and is non-toxic in common laboratory animal models.
Drug Solubility Enhancement
This cyclodextrin derivative forms a guest-host complex with lipophilic drugs, significantly increasing their solubility in aqueous solutions. This complexation is key for pharmaceutical formulations requiring improved bioavailability.
Analytical and Chromatographic Applications
Utilised in analytical chemistry, including capillary electrophoresis, as a chiral mobile phase additive or complexing agent to improve separation of chiral compounds.
Cell Culture
Its suitability for cell culture makes it a valuable component in cell-based assays and research where controlled delivery or enhanced solubility of specific reagents is needed.
Chemical Synthesis
Can be employed as a reagent in chemical synthesis, particularly in reactions benefiting from supramolecular complexation or phase transfer catalysis.
| Solubility | H2O: soluble100 mg/mL |
|---|---|
| Application | The solubility of lipophilic drugs increases linearly with the concentration of hydroxypropyl-β-cyclodextrin (HBC) in aqueous solution because of the complex between HBC and the drug. This guest-host type complex is formed between the drug and the non-polar cavity in the HBC that results in enhanced solubility. Solutions may be lyophilized to produce freely soluble powders. Non-toxic in rabbits and mice. |
| Suitability | suitable for cell culture |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Mol Wt | average Mw ~1,460 |
|---|---|
| Extent Of Labeling | 0.8 molar substitution |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (2-Hydroxypropyl)-β-cyclodextrin primarily used for?
+
(2-Hydroxypropyl)-β-cyclodextrin is primarily used to enhance the solubility of lipophilic compounds through complexation and is also utilised in analytical and chromatographic applications, as well as in cell culture.
What are the CAS number and molecular formula for (2-Hydroxypropyl)-β-cyclodextrin?
+
The CAS number for (2-Hydroxypropyl)-β-cyclodextrin is 128446-35-5. The molecular formula is not provided in the product data.
What grade and purity does Tech Serve Solutions supply for (2-Hydroxypropyl)-β-cyclodextrin?
+
Tech Serve Solutions supplies (2-Hydroxypropyl)-β-cyclodextrin with an average Mw of ~1,460 and 0.8 molar substitution. We do not specify pharmacopoeial grades (USP, BP, EP) unless explicitly stated in the product data. This product is typically considered for research and laboratory use.
What are the safety and handling recommendations for (2-Hydroxypropyl)-β-cyclodextrin?
+
For safe handling of (2-Hydroxypropyl)-β-cyclodextrin, it is recommended to use eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used if airborne exposure is possible. The substance has a WGK Germany rating of 3.
How is (2-Hydroxypropyl)-β-cyclodextrin typically supplied and exported?
+
(2-Hydroxypropyl)-β-cyclodextrin is packed and exported according to industry standards for fine chemicals, ensuring stability and compliance during transit. Specific packaging details are available upon request.
How can I request a sample or quote for (2-Hydroxypropyl)-β-cyclodextrin?
+
To request a sample or a quote for (2-Hydroxypropyl)-β-cyclodextrin, please contact our sales department through the TSS website or by direct inquiry, providing your specific requirements.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis