(2-Hydroxypropyl)-γ-cyclodextrin

CAS 128446-34-4Chemical Synthesis

(2-Hydroxypropyl)-γ-cyclodextrin (CAS: 128446-34-4) is a modified cyclodextrin derivative with an average molecular weight of approximately 1,580 g/mol and a degree of molar substitution of 0.6. It exhibits notable optical activity, with [α]20/D +145°. This compound is primarily recognised for its utility in analytical chemistry, particularly in chromatography and capillary electrophoresis, and as a synthetic reagent.

IUPAC: HGC

Email us

(2-Hydroxypropyl)-γ-cyclodextrin — chemical structure, CAS 128446-34-4; Chemistry, fine chemical supplied by Tech Serve Solutions

Analytical ReagentsAnalytical/ChromatographyCapillary ElectrophoresisChemical SynthesisCyclodextrinsSynthetic Reagents More...

01 /Applications

Chromatographic Applications

(2-Hydroxypropyl)-γ-cyclodextrin serves as a chiral mobile phase additive in High-Performance Liquid Chromatography (HPLC) and Gas Chromatography (GC) for enantiomeric separations. Its ability to form inclusion complexes aids in resolving chiral compounds.

Capillary Electrophoresis

In capillary electrophoresis (CE), this derivative acts as a chiral selector to differentiate enantiomers. Its complexation properties contribute to the separation of stereoisomers in CE systems.

Chemical Synthesis

As a synthetic reagent, (2-Hydroxypropyl)-γ-cyclodextrin can be employed in various organic synthesis pathways. Its structure allows for host-guest chemistry and modification for specific synthetic targets.

Chelation and Complexation

This compound can participate in chelation and complexation reactions, forming stable inclusion complexes with a variety of guest molecules. This property is leveraged in analytical methods and separation science.

02 /Properties

Optical activity	[α]20/D +145°, c = 1 in H2O

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

128446-34-4

05 /Additional specifications

Mol Wt	average Mw ~1,580
Extent Of Labeling	0.6 molar substitution

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is (2-Hydroxypropyl)-γ-cyclodextrin used for?

(2-Hydroxypropyl)-γ-cyclodextrin is primarily used as a chiral selector in chromatography and capillary electrophoresis, and as a synthetic reagent. It also finds application in chelation and complexation chemistry.

What are the CAS number and chemical formula for this compound?

The CAS number for (2-Hydroxypropyl)-γ-cyclodextrin is 128446-34-4. The chemical formula is not provided in the product data.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies (2-Hydroxypropyl)-γ-cyclodextrin with an average Mw of ~1,580 and a molar substitution of 0.6. TSS does not represent this product as USP/BP/EP or any pharmacopoeia grade; it is supplied for research and analytical purposes.

What are the safety and handling recommendations for (2-Hydroxypropyl)-γ-cyclodextrin?

For safe handling, it is recommended to use eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used. This compound is classified under WGK Germany 3, indicating a high hazard to water.