2-Fluoro-5-iodobenzoyl chloride
2-Fluoro-5-iodobenzoyl chloride (CAS: 186584-73-6) is a specialised organic compound with the linear formula FC<sub>6</sub>H<sub>3</sub>(I)COCl and a molecular weight of 284.45 g/mol. This acid halide serves as a key building block in organic synthesis, particularly for creating complex fluorinated molecules. It is primarily utilised as a reactant in the preparation of biologically and pharmacologically active compounds and in specific coupling reactions, offering precision for advanced chemical research and development.
Preparation of Bioactive Molecules
2-Fluoro-5-iodobenzoyl chloride is employed as a crucial intermediate in the synthesis of compounds exhibiting biological and pharmacological activity. Its structure allows for the introduction of fluorinated and iodinated phenyl moieties into potential drug candidates.
Microwave-Assisted Coupling Reactions
This compound is a suitable reactant for microwave-assisted boron trichloride mediated coupling reactions. These reactions are often employed to efficiently form new carbon-carbon or carbon-heteroatom bonds in complex synthetic pathways.
Fluorinated Organic Synthesis
As a fluorinated building block, it is valuable for constructing molecules where fluorine incorporation is desired to modulate properties such as metabolic stability, lipophilicity, and binding affinity.
| Molecular weight | 284.45 |
|---|---|
| Linear formula | FC6H3(I)COCl |
| Assay | 97% |
| Application | Reactant for:• Preparation of biologically and pharmacologically active molecules1,2,3,4,5• Microwave-assisted boron trichloride mediated coupling reactions6 |
| Melting point | 30-34 °C(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Fluoro-5-iodobenzoyl chloride used for?
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2-Fluoro-5-iodobenzoyl chloride is used as a reactant in the preparation of biologically and pharmacologically active molecules and in microwave-assisted boron trichloride mediated coupling reactions. It serves as a key building block in organic synthesis, especially for fluorinated compounds.
What are the CAS number and chemical formula for 2-Fluoro-5-iodobenzoyl chloride?
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The CAS number for 2-Fluoro-5-iodobenzoyl chloride is 186584-73-6, and its linear formula is FC<sub>6</sub>H<sub>3</sub>(I)COCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Fluoro-5-iodobenzoyl chloride with an assay of 97%. This product is supplied for research and laboratory purposes and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How is 2-Fluoro-5-iodobenzoyl chloride handled and stored safely?
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2-Fluoro-5-iodobenzoyl chloride is classified as Danger (GHS05) and causes severe skin burns and eye damage (H314). Handling requires appropriate personal protective equipment, including eyeshields, a face shield, and chemical-resistant gloves. Work should be conducted in a well-ventilated area, and respiratory protection (e.g., N100 or P3 filters) is recommended. Store in a cool, dry place away from incompatible materials.
Does Tech Serve Solutions export 2-Fluoro-5-iodobenzoyl chloride?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 2-Fluoro-5-iodobenzoyl chloride, serving customers worldwide.
How can I request a quote or sample for 2-Fluoro-5-iodobenzoyl chloride?
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To request a quote or sample, please contact our sales team via the website or direct email. Provide the product name, CAS number (186584-73-6), and desired quantity.
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