2-Di(tert-butyl)phosphino-2′,4′,6′-triisopropyl-3-methoxy-6-methylbiphenyl
2-Di(tert-butyl)phosphino-2′,4′,6′-triisopropyl-3-methoxy-6-methylbiphenyl (CAS: 1262046-34-3) is a sophisticated organophosphorus compound with the molecular formula C31H49OP and a molecular weight of 468.69 g/mol. As a member of the Buchwald ligand family, it is highly valued in organic synthesis for its efficacy in catalysing cross-coupling reactions, particularly those involving challenging substrates. Its unique structural features contribute to its effectiveness in facilitating C-C, C-N, and C-O bond formations.
- IUPAC
- Di-tert-butyl(2′,4′,6′-triisopropyl-3-methoxy-6-methyl-[1,1′-biphenyl]-2-yl)phosphine,RockPhos
- Synonyms
- 1262046-34-3C31H49OPDi-tert-butyl(2′,4′,6′-triisopropyl-3-methoxy-6-methyl-[1,1′-biphenyl]-2-yl)phosphineRockPhos
Palladium-Catalysed Cross-Coupling Reactions
This phosphine ligand is frequently employed in palladium-catalysed cross-coupling reactions such as Suzuki-Miyaura, Buchwald-Hartwig amination, and Sonogashira couplings. It facilitates the formation of new carbon-carbon and carbon-heteroatom bonds, crucial for constructing complex organic molecules.
Organic Synthesis and Pharmaceutical Intermediates
Its utility extends to the synthesis of advanced pharmaceutical intermediates and fine chemicals. The ligand's ability to promote high yields and selectivity under mild conditions makes it a valuable tool for medicinal chemists and process development scientists.
Catalysis Research
Researchers utilise this compound to explore new catalytic methodologies and optimise existing ones. Its specific steric and electronic properties allow for fine-tuning of catalytic activity and stability in various reaction systems.
| Molecular weight | 468.69 |
|---|---|
| Empirical formula | C31H49OP |
| Assay | 97% |
| Melting point | 121-131 °C |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Di(tert-butyl)phosphino-2′,4′,6′-triisopropyl-3-methoxy-6-methylbiphenyl used for?
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This compound is primarily used as a ligand in palladium-catalysed cross-coupling reactions, such as Suzuki-Miyaura and Buchwald-Hartwig aminations, for the synthesis of complex organic molecules, including pharmaceutical intermediates.
What is the CAS number and formula for this product?
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The CAS number is 1262046-34-3, and the empirical formula (Hill notation) is C31H49OP.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product with an assay of 97%. It is typically considered a research or technical grade chemical and is not represented as USP, BP, or EP grade.
How should 2-Di(tert-butyl)phosphino-2′,4′,6′-triisopropyl-3-methoxy-6-methylbiphenyl be handled?
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This compound is classified under Water Hazard Class 3 (WGK Germany), indicating it is hazardous to aquatic life. Handle with appropriate personal protective equipment in a well-ventilated area, avoiding release into the environment. Refer to the Safety Data Sheet for detailed handling and storage instructions.
Does Tech Serve Solutions export this chemical?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including this product.
How can I request a quote or sample?
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Please contact our sales team via the website or by phone to request a quote or inquire about sample availability.
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