2-Chloro-1,3,2-dioxaphospholane
2-Chloro-1,3,2-dioxaphospholane (CAS: 822-39-9) is a valuable organophosphorus compound with the empirical formula C2H4ClO2P and a molecular weight of 126.48 g/mol. This cyclic chlorophosphite is primarily employed as a phosphitylating agent in organic synthesis. Its applications include the preparation of phosphocholines and spirophosphoranes, making it a key reagent in fields such as catalysis and inorganic chemistry.
- IUPAC
- Cyclic ethylene chlorophosphite,Cyclic ethylene phosphorochloridite,Ethylene chlorophosphite,Ethylene glycol chlorophosphite
- Synonyms
- 822-39-9C2H4ClO2PCyclic ethylene chlorophosphiteCyclic ethylene phosphorochloriditeEthylene chlorophosphiteEthylene glycol chlorophosphite
Synthesis of Phosphocholines
2-Chloro-1,3,2-dioxaphospholane serves as a crucial phosphitylating agent for the synthesis of phosphocholine derivatives. These compounds are important in biological and pharmaceutical research.
Preparation of Spirophosphoranes
This reagent is utilised in the formation of spirophosphorane structures. Spirocyclic phosphorus compounds have diverse applications in catalysis and materials science.
Catalysis and Inorganic Chemistry
As a phosphorus precursor, it finds utility in developing novel catalytic systems and in the synthesis of various inorganic phosphorus-containing materials.
Chemical Synthesis
Its reactive nature makes it a versatile building block for introducing phosphityl groups in complex organic molecules during multi-step syntheses.
| Molecular weight | 126.48 |
|---|---|
| Empirical formula | C2H4ClO2P |
| Assay | 97% |
| Boiling point | 62 °C/20 mmHg(lit.) |
| Density | 1.422 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.489(lit.) |
| Storage temperature | 2-8°C |
| Application | Phosphitylating agent used in the synthesis of phosphocholines1,2 and spirophosphoranes.3 |
Hazard statements
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 86 °C / 186.8 °F |
| Transport (UN / ADR) | UN 3264 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 14-34-37 |
| Safety statements (S) | 26-36/37/39-45 |
| Supplemental hazards | Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Chloro-1,3,2-dioxaphospholane used for?
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2-Chloro-1,3,2-dioxaphospholane is used as a phosphitylating agent in the synthesis of phosphocholines and spirophosphoranes, and in catalysis and chemical synthesis.
What is the CAS number and formula for 2-Chloro-1,3,2-dioxaphospholane?
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The CAS number is 822-39-9 and the empirical formula is C2H4ClO2P.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Chloro-1,3,2-dioxaphospholane with an assay of 97%. It is supplied as a research or technical grade and TSS does not represent it as USP, BP, or EP grade.
How should 2-Chloro-1,3,2-dioxaphospholane be handled safely?
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2-Chloro-1,3,2-dioxaphospholane is corrosive and can cause severe burns. It reacts violently with water. Handle with appropriate personal protective equipment including face shields, goggles, gloves, and a suitable respirator. Ensure adequate ventilation. Store at 2-8°C.
How is 2-Chloro-1,3,2-dioxaphospholane packed and shipped?
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2-Chloro-1,3,2-dioxaphospholane is shipped as a hazardous material (UN 3264, Class 8, Packing Group II) in compliance with international regulations for hazardous goods transport.
How can I request a sample or quote for 2-Chloro-1,3,2-dioxaphospholane?
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Please contact our sales department via the website or email to request a sample or a quote for 2-Chloro-1,3,2-dioxaphospholane.
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