2-Chloro-1,3,2-benzodioxaphosphorin-4-one
2-Chloro-1,3,2-benzodioxaphosphorin-4-one (CAS 5381-99-7) is a phosphorus-containing organic compound with the molecular formula C7H4ClO3P and a molecular weight of 202.53 g/mol. This compound serves as a valuable reagent in chemical synthesis, primarily for phosphorylation and phosphitylation reactions involving alcohols. It is also employed in the formation of H-phosphonates. Tech Serve Solutions supplies this chemical with an assay of 95%.
- IUPAC
- SalPCl,Salicyl chlorophosphite
- Synonyms
- 5381-99-7C7H4ClO3PSalPClSalicyl chlorophosphite
Phosphorylation and Phosphitylation
This compound acts as an effective reagent for introducing phosphoryl or phosphityl groups onto alcohol molecules. This process is crucial in the synthesis of various organophosphorus compounds.
H-Phosphonate Formation
It is utilized in the synthesis of H-phosphonates, which are important intermediates in organic chemistry, particularly in the development of nucleoside analogues and other biologically active molecules.
Reagent in Organic Synthesis
As a versatile organophosphorus compound, it finds application in a range of synthetic methodologies within academic and industrial research settings.
| Molecular weight | 202.53 |
|---|---|
| Empirical formula | C7H4ClO3P |
| Assay | 95% |
| Boiling point | 127-128 °C/11 mmHg(lit.) |
| Storage temperature | 2-8°C |
| Application | Reagent used in phosphorylation and phosphitylation of alcohols and in the formation of H-phosphonates. |
| Melting point | 36-40 °C(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 3261 8 / PGI |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 14-34 |
| Safety statements (S) | 26-36/37/39-43-45 |
| Supplemental hazards | Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Chloro-1,3,2-benzodioxaphosphorin-4-one used for?
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2-Chloro-1,3,2-benzodioxaphosphorin-4-one (CAS 5381-99-7) is used as a reagent in phosphorylation and phosphitylation of alcohols, and in the formation of H-phosphonates.
What is the CAS number and molecular formula for 2-Chloro-1,3,2-benzodioxaphosphorin-4-one?
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The CAS number is 5381-99-7 and the empirical formula is C7H4ClO3P.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Chloro-1,3,2-benzodioxaphosphorin-4-one with an assay of 95%. This product is not intended for USP, BP, EP, or other pharmacopoeia applications unless explicitly stated.
How should 2-Chloro-1,3,2-benzodioxaphosphorin-4-one be handled safely?
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This compound is classified as Danger (GHS05) and causes severe skin burns and eye damage (H314). It reacts violently with water. Appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection, must be used. Handle only in well-ventilated areas or under a fume hood, and keep away from moisture.
Is this product regulated or scheduled?
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Based on the provided data, there is no indication of specific controlled substance scheduling. However, users should always verify local regulations.
How is 2-Chloro-1,3,2-benzodioxaphosphorin-4-one packed and shipped?
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As a global supplier, Tech Serve Solutions adheres to all relevant shipping regulations for hazardous materials, ensuring safe and compliant packing and export.
How can I request a sample or quote for 2-Chloro-1,3,2-benzodioxaphosphorin-4-one?
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To request a sample or obtain a quotation, please contact our sales department through the website or by phone, providing the product name and CAS number (5381-99-7).
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