(E)-4-Chloro-α-(4-fluorophenyl)cinnamonitrile
(E)-4-Chloro-α-(4-fluorophenyl)cinnamonitrile (CAS: 366-21-2) is a nitrile compound with the molecular formula FC6H4C(CN)=CHC6H4Cl and a molecular weight of 257.69 g/mol. This organic molecule serves as a valuable building block in chemical synthesis, particularly within the realm of organic chemistry. Its structure, featuring halogen and nitrile functionalities, makes it a versatile intermediate for the development of more complex chemical entities in research and industrial applications.
- IUPAC
- E-α-(4-Fluorophenyl)-4-chlorocinnamonitrile

Organic Synthesis Intermediate
Used as a key intermediate in multi-step organic syntheses for creating novel compounds. Its reactive nitrile and halogen groups allow for diverse chemical transformations.
Research and Development
Applied in academic and industrial R&D laboratories for exploring new synthetic pathways and developing novel materials or active pharmaceutical ingredients.
Fine Chemical Manufacturing
Manufactured as a fine chemical for use in the production of specialised chemical products. Its properties are leveraged in various fine chemical manufacturing processes.
| Molecular weight | 257.69 |
|---|---|
| Linear formula | FC6H4C(CN)=CHC6H4Cl |
| Assay | 97% |
| Melting point | 108-112 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (E)-4-Chloro-α-(4-fluorophenyl)cinnamonitrile used for?
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(E)-4-Chloro-α-(4-fluorophenyl)cinnamonitrile is primarily used as a building block and intermediate in organic synthesis and chemical research and development.
What is the CAS number and molecular formula?
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The CAS number is 366-21-2, and the molecular formula is FC6H4C(CN)=CHC6H4Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound at an assay of 97%. We do not represent it as USP, BP, EP, or any pharmacopoeia grade.
What are the safety considerations for handling this chemical?
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Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Please consult the Safety Data Sheet for comprehensive information.
How is (E)-4-Chloro-α-(4-fluorophenyl)cinnamonitrile packed and shipped?
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We pack and ship chemicals professionally, adhering to all relevant regulations for safe transport. Specific packing configurations are available upon request.
How can I request a quote or sample?
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To request a quote or sample, please contact our sales team through the website or by phone, providing the product name and CAS number.
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