2-Cyano-6-methoxybenzothiazole
2-Cyano-6-methoxybenzothiazole (CAS: 943-03-3; Formula: C9H6N2OS; Molar Mass: 190.22 g/mol) is a heterocyclic organic compound. It serves as a key building block in chemical synthesis, particularly for creating complex molecules. Its utility is demonstrated in the preparation of firefly luciferin and related compounds, which are employed in advanced enzyme assay technologies.
- IUPAC
- 6-Methoxy-2-benzothiazolecarbonitrile
- Synonyms
- 6-Methoxy-2-benzothiazolecarbonitrile
Synthesis of Firefly Luciferin
This compound is a precursor in the synthesis of firefly luciferin, the light-emitting substrate in bioluminescence reactions. This is achieved through condensation with cysteine.
Development of Luciferin Derivatives
It has been utilised in the synthesis of luciferin beta-glycosides. These derivatives function as substrates for highly sensitive enzyme assays, enabling precise biological and chemical analyses.
Heterocyclic Building Block
As a benzothiazole derivative, it functions as a valuable intermediate in organic synthesis for constructing more elaborate heterocyclic systems.
| Molecular weight | 190.22 |
|---|---|
| Empirical formula | C9H6N2OS |
| Assay | 99% |
| Solubility | chloroform: soluble5%, clear, colorless to faintly yellow |
| Application | 2-Cyano-6-methoxybenzothiazole has been used in the synthesis of:• firefly luciferin via condensation with cysteine1• luciferin β-glycosides, substrates for novel ultrasensitive enzyme assays2 |
| Melting point | 129-131 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Cyano-6-methoxybenzothiazole used for?
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2-Cyano-6-methoxybenzothiazole is primarily used as a building block in chemical synthesis, notably for the preparation of firefly luciferin and its derivatives, which are important in enzyme assays.
What are the CAS number and molecular formula for 2-Cyano-6-methoxybenzothiazole?
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The CAS number is 943-03-3, and the molecular formula is C9H6N2OS.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Cyano-6-methoxybenzothiazole with an assay of 99%. We do not represent this product as USP, BP, or EP grade.
How should 2-Cyano-6-methoxybenzothiazole be handled safely?
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Handle with appropriate personal protective equipment, including a dust mask (N95 type), eyeshields, and gloves. Avoid inhalation of dust, skin contact, and eye contact, as it is harmful if swallowed, in contact with skin, or inhaled, and causes skin, eye, and respiratory irritation.
Is 2-Cyano-6-methoxybenzothiazole a controlled substance?
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The provided data does not indicate that 2-Cyano-6-methoxybenzothiazole is a controlled substance.
How is this chemical packed, shipped, and exported?
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This chemical is carefully packed according to industry standards to ensure safe transit and is available for global export by Tech Serve Solutions.
How can I request a sample or quote for 2-Cyano-6-methoxybenzothiazole?
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You can request a sample or a quote by contacting our sales team through the website or by calling us directly. Please provide the product name and CAS number.
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