2-Chlorothiophene
2-Chlorothiophene (CAS: 96-43-5), with the molecular formula C4H3ClS and a molecular weight of 118.58 g/mol, is a halogenated heterocyclic compound. It serves as a valuable building block in organic synthesis, particularly for creating complex thiophene derivatives. This chemical is essential for researchers and manufacturers in the fine chemical and pharmaceutical intermediate sectors requiring precise molecular structures for their research and development activities.
- IUPAC
- 2-Thienyl chloride
- Synonyms
- 2-Thienyl chloride

Synthesis of Thiophene Derivatives
2-Chlorothiophene is employed as a key intermediate in the preparation of various substituted thiophene compounds. For instance, it has been utilised in the synthesis of 5-phenylthiophene derivatives, demonstrating its utility in constructing specific molecular architectures.
Heterocyclic Chemistry Research
As a halogenated heterocycle, 2-Chlorothiophene is a crucial reagent for researchers exploring novel synthetic routes and functionalising thiophene rings. Its reactivity allows for diverse chemical transformations.
Building Block for Fine Chemicals
This compound functions as a versatile building block in the broader field of fine chemical synthesis. Its specific structure and reactivity make it suitable for incorporation into more complex target molecules.
| Molecular weight | 118.58 |
|---|---|
| Empirical formula | C4H3ClS |
| Assay | 96% |
| Boiling point | 127-129 °C(lit.) |
| Density | 1.286 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.547(lit.) |
| Storage temperature | 2-8°C |
| Application | 2-Chlorothiophene was used in the preparation of 5-phenylthiophene derivative1. |


Hazard statements
- H226Flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 23 °C / 73.4 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 10-36/37/38 |
| Safety statements (S) | 16-26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Chlorothiophene primarily used for?
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2-Chlorothiophene is primarily used as a building block in organic synthesis, particularly for the preparation of substituted thiophene derivatives and other heterocyclic compounds.
What is the CAS number and formula for 2-Chlorothiophene?
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The CAS number for 2-Chlorothiophene is 96-43-5, and its molecular formula is C4H3ClS.
What grade and purity does Tech Serve Solutions supply for 2-Chlorothiophene?
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Tech Serve Solutions supplies 2-Chlorothiophene with an assay of 96%. We do not represent this product as USP, BP, or EP grade.
How should 2-Chlorothiophene be handled safely?
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2-Chlorothiophene is a flammable liquid and vapour (H226), causes skin irritation (H315), and serious eye irritation (H319), and may cause respiratory irritation (H335). Handle with appropriate personal protective equipment, including safety glasses, gloves, and a suitable respirator, in a well-ventilated area. Store away from heat and open flames.
Is 2-Chlorothiophene available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 2-Chlorothiophene, adhering to all necessary regulations for international shipment.
How can I request a quote or sample for 2-Chlorothiophene?
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To request a quote or sample of 2-Chlorothiophene, please contact our sales team via the website or telephone number provided.
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