Sinefungin

CAS 58944-73-3C15H23N7O5Biochemicals & Reagents

Sinefungin (CAS: 58944-73-3), a nucleoside antibiotic with the molecular formula C15H23N7O5, is a potent inhibitor of methyltransferases. It functions as an S-adenosylmethionine analogue, interfering with essential biological processes. This compound is utilised in research for its ability to inhibit global methyltransferases, particularly in studies involving breast cancer cell lines and other cellular systems. Sinefungin is supplied by TSS as a high-purity research chemical.

IUPAC: 5′-Deoxy-5′-(1,4-diamino-4-carboxybutyl)adenosine,A-9145,Adenosylornithine,Antibiotic 32232RP

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Sinefungin (C15H23N7O5) — chemical structure, CAS 58944-73-3; Life Science, fine chemical supplied by Tech Serve Solutions

AntibioticsAntibiotics A to ZAntibiotics N-SBioactive Small MoleculesBiochemicals and ReagentsCell BiologyChemical Structure ClassGene RegulationInhibits an EnzymeMechanism

01 /Applications

Inhibition of Methyltransferases

Sinefungin has been employed to investigate the role of global methyltransferases in cellular processes, notably in breast cancer cell lines such as MCF7 and Jurkat cells. Its mechanism involves acting as an analogue of S-adenosylmethionine.

Biochemical Research

As an S-adenosylmethionine analogue, Sinefungin is utilised in equilibrium FRET experiments to study enzyme mechanisms and interactions. It serves as a valuable tool for biochemical research into methylation pathways.

Antiparasitic and Antiprotozoal Studies

Categorised as an antiparasitic, antiprotozoal, and anthelminthic agent, Sinefungin's properties make it a subject of interest for research into novel therapeutic agents against various parasitic infections.

02 /Properties

Molecular weight	381.39
Empirical formula	C15H23N7O5
Assay	95% (HPLC)
Form	powder
Colour	white to yellow
Solubility	H2O: complete20 mg/ml, clear, colorless to light yellowH2O: soluble
Storage temperature	2-8°C
Application	Sinefungin was used to inhibit global methyltransferases in breast cancer cell line, MCF72 and Jurkat cells.3 It was used as S-adenosylmethionine analogue in equilibrium FRET experiments.4

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H302Harmful if swallowed

Protective equipment	dust mask type N95 (US), Eyeshields, Gloves
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xn
Risk statements (R)	22
Safety statements (S)	36

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

58944-73-3

PubChem substance

24899800

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Sinefungin primarily used for?

Sinefungin is primarily used in research to inhibit global methyltransferases and as an S-adenosylmethionine analogue in biochemical studies. It has also been investigated for antiparasitic properties.

What are the CAS number and molecular formula for Sinefungin?

The CAS number for Sinefungin is 58944-73-3, and its molecular formula is C15H23N7O5.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Sinefungin with an assay of 95% (HPLC). We do not represent this product as USP, BP, or EP grade.

How should Sinefungin be handled and stored?

Sinefungin is classified as harmful if swallowed (H302) and requires appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves. It should be stored at 2-8°C.

Is Sinefungin a controlled substance?

The provided data does not indicate that Sinefungin is a controlled substance.

How can I request a quote or sample for Sinefungin?

To request a quote or sample of Sinefungin, please contact our sales team through the website or by phone.

How is Sinefungin typically packaged and shipped?

Sinefungin is supplied as a white to yellow powder. It is carefully packaged for safe transport and export, adhering to all relevant shipping regulations.