Sertindole
Sertindole (CAS: 106516-24-9), with a molecular weight of 440.94 g/mol and the empirical formula C24H26ClFN4O, is an off-white solid chemical. Primarily utilised in research settings, it serves as a valuable tool for investigating neurotransmission and receptor activity, particularly concerning dopamine and serotonin pathways. Its applications extend to studying antipsychotic mechanisms and potential therapeutic targets within neuroscience.
- IUPAC
- 1-[2-[4-[5-Chloro-1-(4-fluorophenyl)-1h-indol-3-yl]-1-piperidinyl]ethyl]-2-imidazolidinone
Neuroscience Research
Sertindole is employed in laboratory studies to investigate the complex mechanisms of neurotransmission and receptor binding, particularly focusing on dopamine D2 and serotonin 5-HT2 receptors. This helps researchers understand neurological pathways and potential drug targets.
Pharmacological Studies
This compound is used in preclinical research to explore the pharmacological effects of antipsychotic agents. Its specific receptor interactions allow for the study of drug efficacy and side effects, such as its role in receptor-induced body weight changes.
Drug Discovery and Development
As a bioactive small molecule and a potential therapeutic candidate, Sertindole serves as a reference compound or lead structure in the discovery and development of novel neurological drugs. Its known activity profile aids in the design of new chemical entities.
| Molecular weight | 440.94 |
|---|---|
| Empirical formula | C24H26ClFN4O |
| Assay | ≥97.5% (HPLC) |
| Form | solid |
| Colour | off-white |
| Solubility | DMSO: >10 mg/mLH2O: <2 mg/mL |
| Storage temperature | 2-8°C |
| Application | Sertindole was used to study the role of 5-HT2C receptor in antipsychotic-induced body weight gain in rats.3 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H413May cause long-lasting harmful effects to aquatic life
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Sertindole used for?
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Sertindole is used in research for investigating neurotransmission, receptor activity (specifically dopamine and serotonin pathways), and studying the mechanisms of antipsychotic drugs.
What is the CAS number and formula for Sertindole?
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The CAS number for Sertindole is 106516-24-9 and its empirical formula is C24H26ClFN4O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Sertindole with an assay of ≥97.5% (HPLC). We do not represent this product as USP, BP, or EP grade.
How should Sertindole be handled and stored?
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Sertindole should be handled with appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves. It should be stored at refrigerated temperatures (2-8°C) and is a solid of off-white colour.
Does Tech Serve Solutions export Sertindole?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including Sertindole.
How can I request a quote or sample for Sertindole?
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To request a quote or sample for Sertindole, please contact our sales department through the website or by phone.
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