2-Chlorophenylboronic acid
2-Chlorophenylboronic acid (CAS: 3900-89-8), with the molecular formula ClC6H4B(OH)2 and a molecular weight of 156.37 g/mol, is a versatile organoboron compound. It is a key intermediate in organic synthesis, particularly valued for its utility in Suzuki-Miyaura cross-coupling reactions. This white to off-white solid is widely employed in the synthesis of complex organic molecules, pharmaceutical intermediates, and advanced materials, serving as a critical building block for chemists worldwide.
- IUPAC
- (o-Chlorophenyl)boronic acid,2-Chlorobenzeneboronic acid,o-chloro-Benzeneboronic acid
- Synonyms
- (o-Chlorophenyl)boronic acid2-Chlorobenzeneboronic acido-chloro-Benzeneboronic acid
Suzuki-Miyaura Cross-Coupling Reactions
2-Chlorophenylboronic acid is a widely used coupling partner in palladium-catalyzed Suzuki-Miyaura reactions. It facilitates the formation of carbon-carbon bonds, enabling the synthesis of biaryl compounds and substituted aromatic systems crucial in medicinal chemistry and materials science.
Pharmaceutical Intermediate Synthesis
This boronic acid serves as a vital building block in the multi-step synthesis of active pharmaceutical ingredients (APIs). Its ability to introduce the 2-chlorophenyl moiety allows for the construction of complex molecular scaffolds found in various drug candidates.
Organic Synthesis Reagent
Beyond cross-coupling, 2-Chlorophenylboronic acid finds application in various other organic transformations. It is a valuable reagent for chemists involved in the development of novel organic compounds and functional materials.
Materials Science
The compound can be employed in the synthesis of advanced materials, including organic light-emitting diodes (OLEDs) and polymers, where precise structural control and specific electronic properties are required.
| Molecular weight | 156.37 |
|---|---|
| Linear formula | ClC6H4B(OH)2 |
| Assay | ≥95.0% |
| Melting point | 92-102 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Chlorophenylboronic acid used for?
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2-Chlorophenylboronic acid is primarily used as a coupling partner in Suzuki-Miyaura reactions for carbon-carbon bond formation, and as a key intermediate in the synthesis of pharmaceuticals and advanced organic materials.
What is the CAS number and chemical formula for 2-Chlorophenylboronic acid?
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The CAS number is 3900-89-8, and the chemical formula is ClC6H4B(OH)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Chlorophenylboronic acid with an assay of ≥95.0%. This is a technical/research grade product, and TSS does not represent it as USP, BP, or EP grade.
What are the safety considerations when handling 2-Chlorophenylboronic acid?
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Handling 2-Chlorophenylboronic acid requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used. Refer to the Safety Data Sheet for comprehensive handling information.
How is 2-Chlorophenylboronic acid packed, shipped, and exported?
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2-Chlorophenylboronic acid is carefully packed to ensure stability and integrity during transit. Tech Serve Solutions is experienced in exporting fine chemicals globally, adhering to all relevant shipping regulations.
How can I request a quote or sample of 2-Chlorophenylboronic acid?
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To request a quote or a sample of 2-Chlorophenylboronic acid, please use the 'Request a Quote' or 'Request Sample' button on the product page, or contact our sales team directly.
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