2-Chlorophenyl phosphorodichloridate
2-Chlorophenyl phosphorodichloridate (CAS: 15074-54-1) is a chemical compound with the formula Cl2P(O)OC6H4Cl and a molecular weight of 245.43 g/mol. This organophosphorus compound serves as a valuable building block in chemical synthesis, particularly in the preparation of nucleotide and oligonucleotide derivatives. Its reactivity makes it useful for introducing specific chemical functionalities in complex organic molecules.
- IUPAC
- 2-Chlorophenyl dichlorophosphate
Preparation of Mononucleotide Building Blocks
2-Chlorophenyl phosphorodichloridate is employed in the synthesis of essential mononucleotide building blocks. These intermediates are fundamental for further elaboration in nucleic acid chemistry.
Synthesis of Oligonucleotides
This compound is utilized in the preparation of oligonucleotides. Its specific reactivity allows for controlled chain elongation in the synthesis of short DNA or RNA sequences.
Oligonucleotide Phosphorothioate Synthesis
It finds application in the synthesis of oligonucleotide phosphorothioates. This modification is important for enhancing the stability and cellular uptake of therapeutic oligonucleotides.
| Molecular weight | 245.43 |
|---|---|
| Linear formula | Cl2P(O)OC6H4Cl |
| Assay | 99% |
| Boiling point | 135-137 °C/12 mmHg(lit.) |
| Density | 1.491 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.538(lit.) |
| Application | 2-Chlorophenyl phosphorodichloridate has been used in the preparation of:• mononucleotide building blocks1• oligonucleotides and oligonucleotide phosphorothioates in solution2 |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 105 °C / 221 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Chlorophenyl phosphorodichloridate used for?
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2-Chlorophenyl phosphorodichloridate is used as a building block in organic synthesis, primarily for the preparation of mononucleotide and oligonucleotide derivatives, including oligonucleotide phosphorothioates.
What is the CAS number and chemical formula for 2-Chlorophenyl phosphorodichloridate?
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The CAS number is 15074-54-1, and the chemical formula is Cl2P(O)OC6H4Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Chlorophenyl phosphorodichloridate with a minimum assay of 99%. We do not represent this product as USP, BP, or EP grade.
How should 2-Chlorophenyl phosphorodichloridate be handled safely?
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2-Chlorophenyl phosphorodichloridate causes severe skin burns and eye damage (H314). It requires careful handling with appropriate personal protective equipment, including gloves, goggles, a face shield, and suitable respiratory protection. Refer to the Safety Data Sheet for comprehensive guidance.
Is 2-Chlorophenyl phosphorodichloridate shipped internationally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 2-Chlorophenyl phosphorodichloridate, and can facilitate international shipments.
How can I request a quote or sample for 2-Chlorophenyl phosphorodichloridate?
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To request a quote or a sample, please contact our sales department through the website or by phone, providing your specific requirements.
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