2-Chloro-6-fluorobenzylzinc chloride solution
2-Chloro-6-fluorobenzylzinc chloride solution (CAS: 307531-98-2) is an organozinc halide with the linear formula ClC₆H₃(F)CH₂ZnCl and a molecular weight of 244.41 g/mol. This flammable liquid, supplied as a 0.5 M solution in Tetrahydrofuran (THF), is a valuable reagent in organic synthesis. It is primarily utilised for introducing the 2-chloro-6-fluorobenzyl moiety into organic molecules via cross-coupling reactions and other transformations mediated by organozinc compounds.
Organozinc Reagent in Cross-Coupling
This solution serves as a nucleophilic coupling partner in transition-metal catalysed cross-coupling reactions, such as Negishi couplings. It is employed to form new carbon-carbon bonds, incorporating the 2-chloro-6-fluorobenzyl group into complex organic structures.
Synthesis of Pharmaceutical Intermediates
The reagent's specific structure makes it useful for the synthesis of advanced intermediates in the pharmaceutical industry. Its ability to deliver a functionalised benzyl group is key in building target molecules with precise regiochemistry.
Fine Chemical Synthesis
Utilised in the broader field of fine chemical manufacturing, this organozinc compound enables the preparation of specialised organic molecules. Its reactivity profile allows for controlled functionalisation and elaboration of various substrates.
| Molecular weight | 244.41 |
|---|---|
| Linear formula | ClC6H3(F)CH2ZnCl |
| Boiling point | 65 °C |
| Density | 0.991 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P281Use personal protective equipment as required
- P305IF IN EYES
| Flash point | -17 °C / 1.4 °F |
|---|---|
| Transport (UN / ADR) | UN 2056 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-19-36/37-40 |
| Safety statements (S) | 16-26-36/37 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Chloro-6-fluorobenzylzinc chloride solution used for?
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2-Chloro-6-fluorobenzylzinc chloride solution is primarily used as a reagent in organic synthesis, particularly in cross-coupling reactions like Negishi coupling, for introducing the 2-chloro-6-fluorobenzyl group into organic molecules. It is valuable in the synthesis of pharmaceutical intermediates and other fine chemicals.
What are the CAS number and chemical formula?
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The CAS number for 2-Chloro-6-fluorobenzylzinc chloride solution is 307531-98-2. The linear formula is ClC₆H₃(F)CH₂ZnCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Chloro-6-fluorobenzylzinc chloride solution as a 0.5 M concentration in Tetrahydrofuran (THF). TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade; it is suitable for research and chemical synthesis applications.
How should 2-Chloro-6-fluorobenzylzinc chloride solution be handled?
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This solution is a highly flammable liquid and vapour (H225). It can cause serious eye irritation (H319), may cause respiratory irritation (H335), and is suspected of causing cancer (H351). It may also form explosive peroxides. Handle with appropriate personal protective equipment in a well-ventilated area, away from ignition sources. Store refrigerated at 2-8°C.
Is this product controlled or scheduled?
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The provided data does not indicate that 2-Chloro-6-fluorobenzylzinc chloride solution is a controlled or scheduled substance under common regulatory frameworks.
How is this chemical packed and exported?
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2-Chloro-6-fluorobenzylzinc chloride solution is packed and shipped in compliance with regulations for hazardous materials, including UN 2056, Class 3, Packing Group II. Tech Serve Solutions is an experienced global exporter of fine chemicals.
How can I request a sample or quote?
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To request a sample or obtain a quote for 2-Chloro-6-fluorobenzylzinc chloride solution, please contact the Tech Serve Solutions sales team via our website or by phone, referencing the product name and CAS number 307531-98-2.
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