2-Chloro-6-fluoro-3-methylphenylboronic acid
2-Chloro-6-fluoro-3-methylphenylboronic acid (CAS: 352535-85-4), with the molecular formula C6H2ClF(CH3)B(OH)2 and a molecular weight of 188.39 g/mol, is a key organoboronic acid derivative. It is frequently employed in organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions. This compound serves as a valuable building block for constructing complex organic molecules within pharmaceutical and materials science research, offering a versatile route to introduce substituted aryl moieties.
Suzuki-Miyaura Cross-Coupling
This boronic acid is an effective coupling partner in Suzuki-Miyaura reactions, enabling the formation of carbon-carbon bonds with aryl or vinyl halides. It is instrumental in synthesising complex biaryl compounds and other substituted aromatic systems.
Pharmaceutical Intermediate Synthesis
The compound's structure makes it a useful intermediate in the synthesis of active pharmaceutical ingredients (APIs). Its specific substitution pattern can be critical for developing novel drug candidates targeting various therapeutic areas.
Materials Science Research
In materials science, 2-Chloro-6-fluoro-3-methylphenylboronic acid can be utilised in the development of organic electronic materials, such as OLEDs or conductive polymers, where precise molecular architecture is required.
Organic Synthesis Building Block
As a versatile building block, it facilitates the introduction of a specific chloro-fluoro-methylphenyl group into organic molecules. This is valuable for structure-activity relationship studies and lead compound optimisation.
| Molecular weight | 188.39 |
|---|---|
| Linear formula | C6H2ClF(CH3)B(OH)2 |
| Melting point | 150-154 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Chloro-6-fluoro-3-methylphenylboronic acid used for?
+
2-Chloro-6-fluoro-3-methylphenylboronic acid is primarily used as a coupling partner in Suzuki-Miyaura cross-coupling reactions for C-C bond formation, serving as a building block in the synthesis of complex organic molecules, particularly for pharmaceutical and materials science applications.
What are the CAS number and formula for 2-Chloro-6-fluoro-3-methylphenylboronic acid?
+
The CAS number is 352535-85-4 and the linear formula is C6H2ClF(CH3)B(OH)2.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies this chemical for research and development purposes. The specific grade and purity are typically technical or research grade, and TSS does not represent it as USP, BP, EP, or other pharmacopoeial grades unless explicitly stated otherwise in the product specifications.
What are the safety and handling precautions for this compound?
+
This compound is classified under WGK Germany 3. Handling requires appropriate personal protective equipment, including eyeshields and gloves, and a type N95 (US) or type P1 (EN143) respirator filter. Always consult the Safety Data Sheet (SDS) before handling.
How is this product shipped and exported?
+
Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals. Products are carefully packaged according to international shipping regulations to ensure safe transit and are exported worldwide.
How can I request a sample or quote for 2-Chloro-6-fluoro-3-methylphenylboronic acid?
+
To request a sample or a quote, please visit the product page on the Tech Serve Solutions website and use the designated contact form or contact information provided.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis