2-Chloro-5-methoxypyrimidine
2-Chloro-5-methoxypyrimidine (CAS: 22536-65-8) is a halogenated heterocyclic compound with the molecular formula C5H5ClN2O and a molecular weight of 144.56 g/mol. This pyrimidine derivative serves as a crucial building block in organic synthesis. It is commonly employed in the preparation of more complex molecules within the pharmaceutical and agrochemical industries due to its reactive chloro and methoxy functional groups, facilitating diverse chemical transformations.

Pharmaceutical Intermediate
2-Chloro-5-methoxypyrimidine is utilized as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs). Its structure is amenable to various coupling and substitution reactions, enabling the construction of diverse heterocyclic drug candidates.
Agrochemical Synthesis
This compound finds application in the development of novel agrochemicals. The pyrimidine core and reactive chlorine atom allow for the introduction of specific functionalities required for pesticidal or herbicidal activity.
Organic Synthesis Reagent
As a versatile building block, 2-Chloro-5-methoxypyrimidine is used in academic and industrial research for creating new chemical entities. Its functional groups allow for regioselective modifications and the assembly of complex organic frameworks.
| Molecular weight | 144.56 |
|---|---|
| Empirical formula | C5H5ClN2O |
| Assay | 97%97% |


Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H318Causes serious eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 37/38-41 |
| Safety statements (S) | 26-39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Chloro-5-methoxypyrimidine used for?
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2-Chloro-5-methoxypyrimidine is primarily used as a building block in organic synthesis, particularly in the pharmaceutical and agrochemical sectors for the preparation of complex molecules and active ingredients.
What are the CAS number and chemical formula for 2-Chloro-5-methoxypyrimidine?
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The CAS number is 22536-65-8 and the chemical formula is C5H5ClN2O.
What grade and purity does Tech Serve Solutions supply for 2-Chloro-5-methoxypyrimidine?
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Tech Serve Solutions supplies 2-Chloro-5-methoxypyrimidine with an assay of 97%. This is a research or technical grade material; we do not represent it as USP, BP, or EP grade.
What are the safety and handling precautions for 2-Chloro-5-methoxypyrimidine?
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2-Chloro-5-methoxypyrimidine is classified as Danger, with hazards including H302 (Harmful if swallowed), H315 (Causes skin irritation), H318 (Causes serious eye damage), and H335 (May cause respiratory irritation). It requires protective equipment such as a dust mask (type N95 US), eyeshields, and gloves. Handle in a well-ventilated area and avoid dust formation.
Is 2-Chloro-5-methoxypyrimidine available for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 2-Chloro-5-methoxypyrimidine, serving customers worldwide.
How can I request a sample or quote for 2-Chloro-5-methoxypyrimidine?
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To request a sample or a quote for 2-Chloro-5-methoxypyrimidine, please contact our sales department via the website or by phone, providing your contact details and the quantity required.
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