2-Chloro-5-(chloromethyl)thiophene
2-Chloro-5-(chloromethyl)thiophene (CAS: 23784-96-5), with the molecular formula C5H4Cl2S and a molecular weight of 167.06 g/mol, is a halogenated thiophene derivative. This compound serves as a valuable building block in organic synthesis, particularly in the preparation of more complex heterocyclic compounds. Its chemical structure lends itself to various coupling and substitution reactions, making it a useful intermediate for researchers in medicinal chemistry and materials science.
Synthesis of Imidazole Derivatives
2-Chloro-5-(chloromethyl)thiophene has been employed in the synthesis of complex organic molecules containing imidazole moieties. For instance, it was used in the preparation of 1-(1,1′-biphenyl-4-yl)-3-(5-chloro-thiophen-2-yl)-2-(1H-imidazol-1-yl)propane.
Intermediate for Propane Derivatives
This compound is a key intermediate in the synthesis of various substituted propane derivatives. It facilitated the creation of compounds such as 1-(5-chlorothiophen-2-yl)-2-(1H-imidazol-1-yl)-3-phenylpropane.
Heterocyclic Chemistry Research
As a functionalised thiophene, 2-Chloro-5-(chloromethyl)thiophene is a useful synthon for chemists exploring novel heterocyclic structures. Its reactivity allows for the introduction of thiophene rings into diverse molecular frameworks.
| Molecular weight | 167.06 |
|---|---|
| Empirical formula | C5H4Cl2S |
| Assay | 97% |
| Boiling point | 83-85 °C/8 mmHg(lit.) |
| Density | 1.385 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.575(lit.) |
| Storage temperature | −20°C |
| Application | 2-Chloro-5-(chloromethyl)thiophene was used in the synthesis of 1-(1,1′-biphenyl-4-yl)-3-(5-chloro-thiophen-2-yl)-2-(1H-imidazol-1-yl)propane and 1-(5-chlorothiophen-2-yl)-2-(1H-imidazol-1-yl)-3-phenylpropane1. |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 101 °C / 213.8 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Chloro-5-(chloromethyl)thiophene used for?
+
2-Chloro-5-(chloromethyl)thiophene is primarily used as a building block in organic synthesis, particularly for the preparation of complex heterocyclic compounds, including imidazole and propane derivatives.
What are the CAS number and formula for 2-Chloro-5-(chloromethyl)thiophene?
+
The CAS number for 2-Chloro-5-(chloromethyl)thiophene is 23784-96-5, and its molecular formula is C5H4Cl2S.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies 2-Chloro-5-(chloromethyl)thiophene with an assay of 97%. We do not represent this product as USP, BP, or EP grade.
How should 2-Chloro-5-(chloromethyl)thiophene be handled safely?
+
2-Chloro-5-(chloromethyl)thiophene is classified as a Warning substance. It causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including eyeshields and gloves, should be worn, and work should be conducted in a well-ventilated area or with a suitable respirator.
Is 2-Chloro-5-(chloromethyl)thiophene a controlled substance?
+
The provided data does not indicate that 2-Chloro-5-(chloromethyl)thiophene is a controlled substance.
How is 2-Chloro-5-(chloromethyl)thiophene packed, shipped, and exported?
+
Tech Serve Solutions, as a specialist global supplier and exporter, packs and ships fine chemicals according to international regulations to ensure safe transit. Specific packaging details are available upon request.
How can I request a sample or quote for 2-Chloro-5-(chloromethyl)thiophene?
+
To request a sample or a quote for 2-Chloro-5-(chloromethyl)thiophene, please contact our sales department via the website or by phone.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis