2,6-Di-tert-butyl-4-methylpyridine
2,6-Di-tert-butyl-4-methylpyridine (CAS: 38222-83-2) is a sterically hindered pyridine derivative with the molecular formula C14H23N and a molecular weight of 205.34 g/mol. This compound is primarily utilised as a non-nucleophilic base in organic synthesis. Its bulky tert-butyl groups effectively shield the nitrogen atom, preventing it from participating in nucleophilic reactions while allowing it to readily accept protons. It finds applications in various chemical transformations requiring a strong, hindered base.
- Synonyms
- 2,6-bis(1,1-dimethylethyl)-4-methylpyridine4-Methyl-2,6-di-tert-butylpyridine
Non-Nucleophilic Base in Organic Synthesis
2,6-Di-tert-butyl-4-methylpyridine serves as a highly effective non-nucleophilic base. Its steric hindrance makes it ideal for proton abstraction without undergoing unwanted nucleophilic side reactions, crucial in sensitive synthetic pathways.
Acid Scavenger
In reactions that generate acidic by-products, this pyridine derivative acts as an efficient acid scavenger. It neutralises generated acids, protecting acid-sensitive reagents or products and driving reactions to completion.
Catalysis
This compound can be employed as a basic catalyst or co-catalyst in specific organic transformations where a bulky, non-nucleophilic base is required to promote reactivity or control reaction pathways.
| Molecular weight | 205.34 |
|---|---|
| Empirical formula | C14H23N |
| Assay | ≥97.0% (GC) |
| Boiling point | 233 °C(lit.) |
| Refractive index | n20/D 1.4763(lit.) |
| Storage temperature | 2-8°C |
| Melting point | 33-36 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 84 °C / 183.2 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,6-Di-tert-butyl-4-methylpyridine used for?
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2,6-Di-tert-butyl-4-methylpyridine is primarily used as a non-nucleophilic base in organic synthesis and as an acid scavenger in chemical reactions.
What is the CAS number and formula for 2,6-Di-tert-butyl-4-methylpyridine?
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The CAS number is 38222-83-2 and the empirical formula is C14H23N.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,6-Di-tert-butyl-4-methylpyridine with an assay of ≥97.0% (GC). We do not represent this product as USP, BP, or EP grade.
How should 2,6-Di-tert-butyl-4-methylpyridine be handled safely?
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This compound is harmful if swallowed, causes skin irritation, causes serious eye irritation, and may cause respiratory irritation (H302-H315-H319-H335). Appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves, should be worn. In case of eye contact, rinse cautiously with water for several minutes, removing contact lenses if present and easy to do. Continue rinsing.
How is 2,6-Di-tert-butyl-4-methylpyridine packed and exported?
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Tech Serve Solutions, as a specialist global supplier and exporter, ensures products are appropriately packed for safe handling, transport, and export, adhering to all relevant regulations.
How can I request a sample or quote for 2,6-Di-tert-butyl-4-methylpyridine?
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Please contact our sales team via the website or direct inquiry to request a sample or obtain a quotation for 2,6-Di-tert-butyl-4-methylpyridine.
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