Difluoroacetic acid

CAS 381-73-7F2CHCO2HAcids & Bases

Difluoroacetic acid (CAS: 381-73-7), with the molecular formula F₂CHCO₂H and a molecular weight of 96.03 g/mol, is a crucial organic acid and synthetic reagent. It is characterised by its two fluorine atoms on the alpha-carbon. This compound serves as a key intermediate in organic synthesis, particularly for introducing the difluoromethyl group into various molecular structures, enabling the creation of complex heterocyclic compounds.

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Difluoroacetic acid (F2CHCO2H) — chemical structure, CAS 381-73-7; Chemistry, fine chemical supplied by Tech Serve Solutions

AcidsAcids & BasesChemical SynthesisOrganic AcidsSynthetic Reagents

01 /Applications

Synthesis of Heterocyclic Compounds

Difluoroacetic acid is instrumental in preparing 2-difluoromethylbenzimidazoles, oxazoles, and thiazoles. This is achieved through reactions with ortho-substituted anilines, typically mediated by triphenylphosphine.

Introduction of Difluoromethyl Group

This acid facilitates the incorporation of the difluoromethyl (-CHF₂) moiety into organic molecules. This capability is valuable in medicinal chemistry and materials science for modifying molecular properties.

Reagent in Organic Synthesis

As a reactive organic acid, it functions as a versatile building block in diverse synthetic pathways. Its unique fluorinated structure offers distinct reactivity compared to non-fluorinated analogues.

02 /Properties

Molecular weight	96.03
Linear formula	F2CHCO2H
Assay	98%
Boiling point	132-134 °C(lit.)
Density	1.526 g/mL at 25 °C(lit.)
Refractive index	n20/D 1.344(lit.)
Application	Used in the preparation of 2-difluoromethylbenzimidazoles, -oxazoles and -thiazoles from ortho-substituted anilines mediated by triphenylphoshine.1
Melting point	−1 °C(lit.)

03 /Safety & handling

GHS hazard pictogram: Corrosive (GHS05) — Corrosive

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves, clothing and eye/face protection
P305IF IN EYES
P310Immediately call a POISON CENTER or doctor

Protective equipment	Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Flash point	78 °C / 172.4 °F
Transport (UN / ADR)	UN 3265 8 / PGII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	C
Risk statements (R)	34
Safety statements (S)	26-36/37/39-45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

381-73-7

MDL number

MFCD00004220

PubChem substance

24848539

Beilstein registry

1098588

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Difluoroacetic acid used for?

Difluoroacetic acid is used in organic synthesis, particularly for the preparation of 2-difluoromethylbenzimidazoles, oxazoles, and thiazoles, and for introducing the difluoromethyl group into organic molecules.

What is the CAS number and chemical formula for Difluoroacetic acid?

The CAS number for Difluoroacetic acid is 381-73-7, and its linear formula is F₂CHCO₂H.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Difluoroacetic acid with an assay of 98%. We do not represent this product as USP, BP, or EP grade.

How should Difluoroacetic acid be handled safely?

Difluoroacetic acid is a corrosive substance (H314) and requires careful handling. Use appropriate personal protective equipment, including faceshields, gloves, goggles, and a suitable respirator. Store and handle away from incompatible materials.