2-Chloro-4-fluorotoluene
2-Chloro-4-fluorotoluene (CAS: 452-73-3), a halogenated aromatic hydrocarbon with the formula CH3C6H3(Cl)F and a molecular weight of 144.57 g/mol, is a valuable building block in organic synthesis. It is primarily utilised as an intermediate in the preparation of other complex molecules, particularly in the fields of pharmaceutical and agrochemical research and development. Its specific structure allows for targeted chemical transformations.
Chemical Synthesis Intermediate
2-Chloro-4-fluorotoluene serves as a key intermediate in multi-step organic syntheses. Its halogen substituents provide reactive sites for various coupling and substitution reactions, enabling the construction of more complex molecular architectures.
Precursor for Benzyl Bromide Derivatives
This compound has been documented for its use in the preparation of 2-chloro-4-fluoro-benzylbromide. This transformation further expands its utility in synthesising functionalised aromatic compounds.
Research and Development Building Block
As an aryl fluorinated building block, 2-Chloro-4-fluorotoluene is employed in research laboratories for the discovery and development of novel chemical entities, including potential new pharmaceuticals and agrochemicals.
| Molecular weight | 144.57 |
|---|---|
| Linear formula | CH3C6H3(Cl)F |
| Assay | 99% |
| Boiling point | 154-156 °C(lit.) |
| Density | 1.197 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.499(lit.) |
| Application | 2-Chloro-4-fluorotoluene has been used in the preparation of 2-chloro-4-fluoro-benzylbromide1. |
Hazard statements
- H226Flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 50 °C / 122 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 10-36/37/38 |
| Safety statements (S) | 16-26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Chloro-4-fluorotoluene used for?
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2-Chloro-4-fluorotoluene is primarily used as an intermediate in chemical synthesis, particularly in the preparation of other organic compounds like 2-chloro-4-fluoro-benzylbromide, and serves as a building block in research and development.
What are the CAS number and chemical formula for 2-Chloro-4-fluorotoluene?
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The CAS number for 2-Chloro-4-fluorotoluene is 452-73-3, and its chemical formula is CH3C6H3(Cl)F.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Chloro-4-fluorotoluene with a purity of 99%. We do not represent this product as USP, BP, or EP grade.
What are the main safety hazards associated with 2-Chloro-4-fluorotoluene?
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2-Chloro-4-fluorotoluene is a flammable liquid and vapour (H226) and is irritating to the skin (H315), eyes (H319), and respiratory system (H335). Appropriate personal protective equipment, including safety goggles, face shields, and suitable gloves and respirators, must be used when handling this chemical.
How is 2-Chloro-4-fluorotoluene packed and shipped?
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2-Chloro-4-fluorotoluene is packed according to relevant safety and transportation regulations and is available for export globally by Tech Serve Solutions.
How can I request a sample or quote for 2-Chloro-4-fluorotoluene?
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To request a sample or a quote for 2-Chloro-4-fluorotoluene, please contact our sales team via the details provided on the Tech Serve Solutions website.
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