2-Chloro-4-hydroxybenzonitrile
2-Chloro-4-hydroxybenzonitrile (CAS: 3336-16-1) is a fine chemical with the molecular formula ClC6H3(OH)CN and a molecular weight of 153.57 g/mol. This organic building block is valuable in chemical synthesis, particularly for introducing the substituted benzonitrile moiety into more complex structures. It serves as a key intermediate in the production of various chemical compounds within research and industrial settings.

Chemical Synthesis Intermediate
2-Chloro-4-hydroxybenzonitrile acts as a versatile intermediate in organic synthesis. Its functional groups allow for diverse chemical transformations, enabling the construction of novel molecules.
Research and Development
Utilised in R&D laboratories for exploring new synthetic routes and developing novel compounds. Its specific structure makes it relevant for studies in medicinal chemistry and material science.
Building Block for Heterocycles
This compound can be employed in the synthesis of various heterocyclic systems. The nitrile and hydroxyl groups offer reactive sites for cyclisation reactions.
| Molecular weight | 153.57 |
|---|---|
| Linear formula | ClC6H3(OH)CN |
| Assay | 98% |
| Melting point | 160 °C (dec.)(lit.) |

Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Chloro-4-hydroxybenzonitrile used for?
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2-Chloro-4-hydroxybenzonitrile is primarily used as an intermediate in chemical synthesis and in research and development for creating novel compounds and exploring synthetic pathways.
What are the CAS number and chemical formula?
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The CAS number for 2-Chloro-4-hydroxybenzonitrile is 3336-16-1, and its chemical formula is ClC6H3(OH)CN.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Chloro-4-hydroxybenzonitrile with an assay of 98%. This product is suitable for research and general chemical synthesis. TSS does not represent this product as USP, BP, or EP grade.
How should 2-Chloro-4-hydroxybenzonitrile be handled?
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Handle 2-Chloro-4-hydroxybenzonitrile with appropriate personal protective equipment, including a dust mask type N95, eyeshields, and gloves. Ensure adequate ventilation to avoid inhalation of dust. It is classified as harmful if swallowed, in contact with skin, or if inhaled, and causes skin and eye irritation.
Is 2-Chloro-4-hydroxybenzonitrile a controlled substance?
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The provided data does not indicate that 2-Chloro-4-hydroxybenzonitrile is a controlled substance.
How is 2-Chloro-4-hydroxybenzonitrile packed and shipped?
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2-Chloro-4-hydroxybenzonitrile is carefully packed to ensure safe transit and is available for global export by Tech Serve Solutions.
How can I request a quote or sample?
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To request a quote or a sample of 2-Chloro-4-hydroxybenzonitrile, please contact the Tech Serve Solutions sales team through our official website or by phone.
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