2-Bromopropionyl chloride
2-Bromopropionyl chloride (CAS 7148-74-5), with the linear formula CH3CHBrCOCl and a molecular weight of 171.42 g/mol, is a reactive acid halide. It serves as a valuable organic building block in chemical synthesis. Notably, it has been employed in the preparation of cellulose macroinitiators for controlled polymerization techniques and in the synthesis of specific amino acid derivatives.
Synthesis of Cellulose Macroinitiators
2-Bromopropionyl chloride has been utilised in the preparation of cellulose macroinitiators. These initiators are essential for homogeneous atom transfer radical polymerization (ATRP), enabling precise control over polymer architecture.
Preparation of Amino Acid Derivatives
This compound can be used in reactions such as the Friedel Crafts acylation for the synthesis of amino acid derivatives, like 2-aminopropionyl polystyrene resin.
Organic Synthesis Building Block
As a versatile acid halide and organic building block, 2-Bromopropionyl chloride is a key reagent in various organic synthesis pathways for introducing the bromopropionyl moiety.
| Molecular weight | 171.42 |
|---|---|
| Linear formula | CH3CHBrCOCl |
| Boiling point | 131-133 °C(lit.) |
| Density | 1.7 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.477(lit.) |
| Application | 2-Bromopropionyl chloride was used to synthesize cellulose macroinitiator for homogeneous atom transfer radical polymerization1. It was used in the synthesis of 2-aminopropionyl polystyrene resin by Friedel Crafts reaction2. |
Hazard statements
- H226Flammable liquid and vapour
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 51 °C / 123.8 °F |
| Transport (UN / ADR) | UN 2920 3(8) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 10-34-36/37 |
| Safety statements (S) | 16-26-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Bromopropionyl chloride used for?
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2-Bromopropionyl chloride is primarily used as an organic building block in chemical synthesis, including the preparation of cellulose macroinitiators for atom transfer radical polymerization and the synthesis of derivatives like 2-aminopropionyl polystyrene resin.
What is the CAS number and formula for 2-Bromopropionyl chloride?
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The CAS number is 7148-74-5, and the linear formula is CH3CHBrCOCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Bromopropionyl chloride as a technical or research grade chemical. We do not represent it as meeting USP, BP, or EP pharmacopoeia standards.
How should 2-Bromopropionyl chloride be handled safely?
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2-Bromopropionyl chloride is a hazardous substance. It is flammable and corrosive, causing severe skin burns and eye damage, and may cause respiratory irritation. Always handle with appropriate personal protective equipment, including gloves, eye protection, and respiratory protection, in a well-ventilated area.
Is 2-Bromopropionyl chloride available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 2-Bromopropionyl chloride, and can fulfil export orders.
How can I request a quote or sample for 2-Bromopropionyl chloride?
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To request a quote or sample, please contact our sales team through the website or by calling our office. Please specify the quantity and intended use.
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