2-Bromo-4-fluorobenzenesulfonyl chloride
2-Bromo-4-fluorobenzenesulfonyl chloride (CAS: 351003-45-7) is an organosulfur compound with the formula BrC6H3(F)SO2Cl and a molecular weight of 273.51 g/mol. This chemical functions as a versatile building block in organic synthesis. Its reactive sulfonyl chloride group and the presence of bromine and fluorine substituents on the aromatic ring make it a valuable intermediate for the preparation of more complex fluorinated organic molecules used in various research and development applications.

Organic Synthesis Intermediate
Utilised as a key building block in the synthesis of novel organic compounds. The presence of the sulfonyl chloride functionality allows for reactions with nucleophiles, enabling the introduction of the 2-bromo-4-fluorobenzenesulfonyl moiety into target molecules. This is particularly relevant in the development of new pharmaceutical candidates and agrochemicals.
Fluorinated Compound Development
Serves as a precursor in the creation of diverse fluorinated organic structures. Fluorine incorporation can significantly alter the physicochemical and biological properties of molecules, making this reagent important for medicinal chemistry and materials science research.
Research and Development
Employed in academic and industrial laboratories for exploratory chemical research. Its specific substitution pattern offers unique reactivity and structural features for the synthesis of complex organic molecules with potential applications in various scientific fields.
| Molecular weight | 273.51 |
|---|---|
| Linear formula | BrC6H3(F)SO2Cl |
| Assay | 97% |
| Boiling point | 264-265 °C(lit.) |
| Density | 1.870 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.578(lit.) |


Hazard statements
- H226Flammable liquid and vapour
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 35 °C / 95 °F |
| Transport (UN / ADR) | UN 2920 3(8) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 10-34 |
| Safety statements (S) | 16-26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Bromo-4-fluorobenzenesulfonyl chloride used for?
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2-Bromo-4-fluorobenzenesulfonyl chloride is primarily used as a building block and intermediate in organic synthesis, particularly for the development of fluorinated organic compounds.
What is the CAS number and chemical formula for 2-Bromo-4-fluorobenzenesulfonyl chloride?
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The CAS number is 351003-45-7 and the chemical formula is BrC6H3(F)SO2Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Bromo-4-fluorobenzenesulfonyl chloride with a minimum assay of 97%. This product is typically considered a research or technical grade and is not represented as USP, BP, or EP.
What are the primary safety concerns when handling this chemical?
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This compound is classified as Danger, presenting hazards including flammability (H226) and severe skin burns and eye damage (H314). Appropriate personal protective equipment, including chemical-resistant gloves, eye protection, and respiratory protection, is essential. Handle in a well-ventilated area.
How is 2-Bromo-4-fluorobenzenesulfonyl chloride packed, shipped, and exported?
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2-Bromo-4-fluorobenzenesulfonyl chloride is carefully packed according to international shipping regulations for hazardous materials. We offer global export services, ensuring compliance with all relevant transportation and customs requirements for chemical products.
How can I request a sample or obtain a quote for 2-Bromo-4-fluorobenzenesulfonyl chloride?
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To request a sample or obtain a quotation, please contact our sales team through the website or call us directly. Provide the product name, CAS number, and desired quantity for prompt service.
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