2-(Boc-amino)ethyl bromide
2-(Boc-amino)ethyl bromide (CAS: 39684-80-5), with the linear formula BrCH₂CH₂NHCO₂C(CH₃)₃ and a molecular weight of 224.10 g/mol, is a valuable organic building block. It features a protected amine and a reactive bromide, making it suitable for introducing a Boc-protected aminoethyl moiety in chemical synthesis. This compound is commonly employed in the fields of chemical biology and linker chemistry.
- IUPAC
- N-Boc-2-bromoethyl-amine,tert-Butyl N-(2-bromoethyl)carbamate
- Synonyms
- tert-Butyl N-(2-bromoethyl)carbamateN-Boc-2-bromoethylamine2-(tert-butoxycarbonylamino)ethyl bromide
Organic Synthesis Building Block
This compound serves as a versatile building block in organic synthesis, enabling the introduction of a protected aminoethyl group into various molecular structures. The Boc protecting group can be readily removed under acidic conditions, revealing a primary amine for further functionalisation.
Bioconjugation and Linker Chemistry
Its bifunctional nature makes it useful in the design and synthesis of linkers and crosslinkers for bioconjugation. The bromide can react with nucleophiles, while the protected amine can be deprotected and subsequently functionalised to attach biomolecules or other entities.
Pharmaceutical Intermediate Synthesis
2-(Boc-amino)ethyl bromide can be employed in the multi-step synthesis of complex pharmaceutical intermediates. Its reactivity profile allows for controlled incorporation into drug candidates or their precursors.
| Molecular weight | 224.10 |
|---|---|
| Linear formula | BrCH2CH2NHCO2C(CH3)3 |
| Assay | ≥97.0% (GC) |
| Storage temperature | −20°C |
| Melting point | 30-32 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Shipped In | wet ice |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-(Boc-amino)ethyl bromide used for?
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2-(Boc-amino)ethyl bromide is primarily used as a building block in organic synthesis, for chemical biology applications, and in the synthesis of linkers and crosslinkers. It allows for the introduction of a Boc-protected aminoethyl group into molecules.
What is the CAS number and formula for 2-(Boc-amino)ethyl bromide?
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The CAS number for 2-(Boc-amino)ethyl bromide is 39684-80-5, and its linear formula is BrCH₂CH₂NHCO₂C(CH₃)₃.
What grade and purity does Tech Serve Solutions supply for 2-(Boc-amino)ethyl bromide?
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Tech Serve Solutions supplies 2-(Boc-amino)ethyl bromide with a purity of ≥97.0% (GC). We do not represent this product as USP, BP, or EP grade.
How should 2-(Boc-amino)ethyl bromide be handled safely?
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Based on its GHS classification (Warning, H302-H315-H319-H335), 2-(Boc-amino)ethyl bromide is harmful if swallowed, causes skin irritation, causes serious eye irritation, and may cause respiratory irritation. Appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, should be worn during handling. Ensure adequate ventilation.
How is 2-(Boc-amino)ethyl bromide shipped and stored?
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2-(Boc-amino)ethyl bromide is shipped in wet ice and should be stored at -20°C.
How can I request a sample or quote for 2-(Boc-amino)ethyl bromide?
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To request a sample or quote for 2-(Boc-amino)ethyl bromide, please contact the Tech Serve Solutions sales team through our website or by phone.
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