2-(Boc-amino)benzylamine

CAS 849020-94-6C12H18N2O2Chemical Synthesis

2-(Boc-amino)benzylamine (CAS: 849020-94-6), with the molecular formula C12H18N2O2 and a molecular weight of 222.28 g/mol, is a protected amine building block. This compound serves as a valuable reactant in complex organic synthesis pathways, particularly for the preparation of novel heterocyclic scaffolds. Its structure facilitates specific reactions, making it a key intermediate in the development of new chemical entities.

IUPAC: (2-Aminomethyl-phenyl)-carbamic acid tert-butyl ester,tert-Butyl N-(2-aminomethylphenyl)carbamate

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2-(Boc-amino)benzylamine (C12H18N2O2) — chemical structure, CAS 849020-94-6; Chemistry, fine chemical supplied by Tech Serve Solutions

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01 /Applications

Synthesis of Fused Quinoxaline-Benzodiazepines

This compound is utilized as a reactant in two-step syntheses to create fused quinoxaline-benzodiazepine and bis-benzodiazepine structures, often employing a double Ugi/Deprotect/Cyclize strategy.

Preparation of Hydroquinazoline Scaffolds

It serves as a precursor in the preparation of hydroquinazoline scaffolds through microwave-promoted Ugi reactions followed by cyclization.

Development of Pyrazinone Inhibitors

The compound is used in the preparation of pyrazinone derivatives investigated as inhibitors of mast cell tryptase.

02 /Properties

Molecular weight	222.28
Empirical formula	C12H18N2O2
Boiling point	238-242 °C
Density	1.054 g/mL at 25 °C
Application	Reactant for:• Two-step syntheses of fused quinoxaline-benzodiazepines and bis-benzodiazepines employing a double UDC (Ugi/Deprotect/Cyclize) strategy1• Preparation of hydroquinazoline scaffolds via microwave-promoted Ugi reaction and cyclization2• Preparation of pyrazinone inhibitors of mast cell tryptase3

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H302Harmful if swallowed
H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves, clothing and eye/face protection

Flash point	71 °C / 159.8 °F
Transport (UN / ADR)	NA 1993 / PGIII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xn
Risk statements (R)	22-43
Safety statements (S)	36/37

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

849020-94-6

MDL number

MFCD04037902

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 2-(Boc-amino)benzylamine used for?

2-(Boc-amino)benzylamine is used as a reactant in organic synthesis, particularly for the preparation of fused quinoxaline-benzodiazepines, hydroquinazoline scaffolds, and pyrazinone inhibitors.

What are the CAS number and formula for 2-(Boc-amino)benzylamine?

The CAS number for 2-(Boc-amino)benzylamine is 849020-94-6, and its molecular formula is C12H18N2O2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies this compound as a technical grade material. We do not represent it as USP, BP, or EP grade. Please refer to the product specifications for available purity information.

What are the safety considerations when handling 2-(Boc-amino)benzylamine?

2-(Boc-amino)benzylamine is classified as a GHS07 (Warning) substance. It is harmful if swallowed (H302) and may cause an allergic skin reaction (H317). Appropriate personal protective equipment, such as gloves and protective clothing (P280), should be worn during handling. Ensure good ventilation.