2-Amino-6-chloropyridine
2-Amino-6-chloropyridine (CAS 45644-21-1), a halogenated pyridine derivative with the molecular formula C5H5ClN2 and a molecular weight of 128.56 g/mol, serves as a valuable building block in organic synthesis. This compound is particularly noted for its application as a substrate in nickel(II)-catalyzed homo-coupling reactions, facilitating the formation of diamino-2,2′-bipyridine structures. Supplied at 97% purity, it is suitable for research and chemical synthesis purposes.
- IUPAC
- 6-Chloro-2-pyridinamine
Organic Synthesis Intermediate
Serves as a key intermediate in the synthesis of complex organic molecules. Its structure allows for diverse chemical transformations, making it valuable in the development of new compounds.
Catalytic Coupling Reactions
Utilised as a substrate in Ni(II)-catalyzed homo-coupling reactions to produce diamino-2,2′-bipyridine. This application is crucial in constructing specific bipyridine frameworks for further chemical modification or complex formation.
Heterocyclic Chemistry
As a halogenated pyridine, it is instrumental in heterocyclic building block chemistry. It enables the introduction of functionalized pyridine rings into larger molecular architectures.
| Molecular weight | 128.56 |
|---|---|
| Empirical formula | C5H5ClN2 |
| Assay | 97% |
| Application | Substrate used in a Ni(II)-catalyzed homo-coupling providing diamino-2,2′-bipyridine.1 |
| Melting point | 69-73 °C |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Amino-6-chloropyridine used for?
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2-Amino-6-chloropyridine (CAS 45644-21-1) is primarily used as a substrate in nickel(II)-catalyzed homo-coupling reactions to synthesise diamino-2,2′-bipyridine, and as a versatile building block in organic and heterocyclic synthesis.
What are the CAS number and formula for 2-Amino-6-chloropyridine?
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The CAS number for 2-Amino-6-chloropyridine is 45644-21-1, and its molecular formula is C5H5ClN2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Amino-6-chloropyridine with an assay of 97%. This product is intended for laboratory and research use; TSS does not represent it as USP, BP, EP or other pharmacopoeia grades.
How should 2-Amino-6-chloropyridine be handled safely?
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2-Amino-6-chloropyridine is classified as a Warning substance with hazards including H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Appropriate personal protective equipment, including a dust mask (N95 US type), eyeshields, and gloves, should be worn. Handle in a well-ventilated area, avoiding dust formation and contact with skin, eyes, and clothing. Ensure P261 (Avoid breathing dust) and P305 + P351 + P338 (IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing) precautions are followed.
Is 2-Amino-6-chloropyridine a controlled substance?
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Based on the provided data, 2-Amino-6-chloropyridine is not indicated as a controlled substance.
How is 2-Amino-6-chloropyridine packed and shipped?
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Tech Serve Solutions exports fine chemicals globally, adhering to all necessary regulations for safe packing and shipping of chemical reagents. Specific packaging details will be provided upon order confirmation.
How can I request a sample or quote for 2-Amino-6-chloropyridine?
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To request a sample or a quote for 2-Amino-6-chloropyridine, please use the 'Contact Us' form on the Tech Serve Solutions website or call our sales department directly.
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