2-Amino-3-hydroxypyridine
2-Amino-3-hydroxypyridine (CAS 16867-03-1), with the molecular formula C5H6N2O and a molar mass of 110.11 g/mol, is a heterocyclic organic compound. It serves as a valuable building block in chemical synthesis. Specifically, it has been utilised as a reagent in the preparation of functionalised coumarins and 1,4-oxazines through reactions involving dimethyl acetylenedicarboxylate and triphenylphosphine.
- IUPAC
- 2-Amino-3-pyridinol
- Synonyms
- 2-Amino-3-pyridinol
Synthesis of Heterocyclic Compounds
2-Amino-3-hydroxypyridine acts as a key intermediate in the synthesis of complex heterocyclic structures. Its reactivity allows for the formation of fused ring systems, pertinent to medicinal chemistry and materials science research.
Reagent in Organic Reactions
This compound has been employed as a reagent in specific organic transformations. An example includes its use in reactions with activated alkynes to generate coumarin and oxazine derivatives.
Pharmaceutical Intermediate Development
As a pyridine derivative with amino and hydroxyl functionalities, it offers potential as a precursor for the development of novel pharmaceutical agents. Its structure can be incorporated into larger molecules with biological activity.
| Molecular weight | 110.11 |
|---|---|
| Empirical formula | C5H6N2O |
| Assay | 98% |
| Application | 2-Amino-3-hydroxypyridine was used as reagent in reaction of dimethyl acetylenedicarboxylate and triphenylphosphine to yield functionalized coumarins and 1,4-oxazines1. |
| Melting point | 168-172 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Amino-3-hydroxypyridine used for?
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2-Amino-3-hydroxypyridine is used as a building block and reagent in chemical synthesis, notably for preparing functionalised coumarins and 1,4-oxazines.
What are the CAS number and molecular formula for 2-Amino-3-hydroxypyridine?
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The CAS number is 16867-03-1 and the molecular formula is C5H6N2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Amino-3-hydroxypyridine with a minimum assay of 98%. This product is supplied for research and laboratory use and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should 2-Amino-3-hydroxypyridine be handled safely?
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Handle 2-Amino-3-hydroxypyridine with appropriate personal protective equipment, including a dust mask (type N95 US recommended), eyeshields, and gloves. It is a warning substance that can cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335).
Is 2-Amino-3-hydroxypyridine a controlled substance?
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Based on the provided data, 2-Amino-3-hydroxypyridine is not indicated as a controlled substance. However, customers should verify local regulations.
How is this chemical packed, shipped, and exported?
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Tech Serve Solutions exports fine chemicals globally. Products are packed according to international shipping regulations to ensure safe transit.
How can I request a sample or quote for 2-Amino-3-hydroxypyridine?
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To request a sample or a quote, please contact our sales department through the website or direct email, providing your requirements.
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