2,6-Difluoroaniline
2,6-Difluoroaniline (CAS: 5509-65-9) is a fluorinated aromatic amine with the molecular formula F₂C₆H₃NH₂ and a molar mass of 129.11 g/mol. This chemical building block is primarily utilised in organic synthesis. Its applications include the preparation of herbicides, kinase inhibitors, and active pharmaceutical intermediates, making it a valuable reagent for researchers and manufacturers in the pharmaceutical and agrochemical industries.
- Synonyms
- 2,6-Difluorobenzenamine1-Amino-2,6-difluorobenzeneF2C6H3NH2
Herbicidal Compound Synthesis
2,6-Difluoroaniline serves as a key intermediate in the synthesis of N-2,6-difluorophenyl-5-methoxy-1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamide, a compound with herbicidal properties.
Kinase Inhibitor Development
This compound has been employed in the creation of various 2,6,9-trisubstituted purine derivatives, which function as inhibitors of p38α kinase, relevant in medicinal chemistry research.
Pharmaceutical Intermediate Production
2,6-Difluoroaniline is utilised in the synthesis of substituted phenylthiomorpholine dioxides, which are active pharmaceutical intermediates.
| Molecular weight | 129.11 |
|---|---|
| Linear formula | F2C6H3NH2 |
| Assay | ≥97% |
| Boiling point | 51-52 °C/15 mmHg(lit.) |
| Density | 1.199 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.508(lit.) |
| Application | 2,6-Difluoroaniline was used in the synthesis of:• N-2,6-difluorophenyl-5-methoxy-1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamide, herbicidal compound1• series of 2,6,9-trisubstituted purine inhibitors of p38α kinase2• substituted phenylthiomorpholine dioxide, an active pharmaceutical intermediate3 |
Hazard statements
- H226Flammable liquid and vapour
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H317May cause an allergic skin reaction
- H332Harmful if inhaled
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 51 °C / 123.8 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 10-20/21/22 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,6-Difluoroaniline primarily used for?
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2,6-Difluoroaniline is primarily used as a chemical building block in organic synthesis for the preparation of herbicides, kinase inhibitors, and active pharmaceutical intermediates.
What are the CAS number and formula for 2,6-Difluoroaniline?
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The CAS number for 2,6-Difluoroaniline is 5509-65-9, and its linear formula is F₂C₆H₃NH₂.
What grade and purity does Tech Serve Solutions supply for 2,6-Difluoroaniline?
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Tech Serve Solutions supplies 2,6-Difluoroaniline with a minimum assay of ≥97%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
What are the primary safety concerns when handling 2,6-Difluoroaniline?
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2,6-Difluoroaniline is classified as flammable (H226) and harmful if swallowed, in contact with skin, or inhaled (H302, H312, H332). It may also cause an allergic skin reaction (H317). Appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection, should be used. It has a flash point of 51 °C (123.8 °F).
Does Tech Serve Solutions export 2,6-Difluoroaniline?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 2,6-Difluoroaniline.
How can I request a quote or sample for 2,6-Difluoroaniline?
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Please contact our sales team via the website or provide your contact details to request a quote or sample of 2,6-Difluoroaniline.
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