2,6-Difluoro-4-methoxyphenylboronic acid
2,6-Difluoro-4-methoxyphenylboronic acid (CAS 406482-20-0) is a specialised organoboronic acid derivative with a molecular weight of 187.94 g/mol. This compound serves as a key building block in organic synthesis, particularly recognised for its role in palladium-catalyzed cross-coupling reactions like the Suzuki and Stille couplings. Its utility is primarily in the development and synthesis of complex organic molecules, including pharmaceutical intermediates.
- Synonyms
- C7H7BF2O32,6-Difluoro-4-methoxyphenylboronic acid406482-20-0
Suzuki-Miyaura Coupling
This aryl boronic acid is an effective coupling partner in Suzuki-Miyaura reactions, enabling the formation of carbon-carbon bonds with aryl or vinyl halides. It is instrumental in synthesising biaryl compounds, which are prevalent in medicinal chemistry.
Stille Coupling Reactions
2,6-Difluoro-4-methoxyphenylboronic acid can also participate in Stille coupling reactions. This allows for the construction of complex organic structures by coupling with organotin reagents, further expanding its synthetic applicability.
Pharmaceutical Intermediate Synthesis
The compound is employed as a reactant in the synthesis of antithrombotic drugs. Its specific structural features make it valuable for introducing the difluoro-methoxyphenyl moiety into drug candidates during their development.
Organic Synthesis Reagent
As a versatile boronic acid derivative, it is used in various other organic transformations requiring the introduction of a substituted phenyl group. Its reactivity profile supports the construction of diverse chemical scaffolds.
| Molecular weight | 187.94 |
|---|---|
| Empirical formula | C7H7BF2O3 |
| Assay | ≥95% |
| Application | Reactant involved in Suzuki and Stille coupling reactions for synthesis of antithrombotic drugs1 |
| Melting point | 125-130 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,6-Difluoro-4-methoxyphenylboronic acid used for?
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This compound is primarily used as a reactant in Suzuki and Stille coupling reactions for the synthesis of organic molecules, notably as an intermediate in the development of antithrombotic drugs.
What is the CAS number and molecular formula for 2,6-Difluoro-4-methoxyphenylboronic acid?
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The CAS number is 406482-20-0, and its empirical formula (Hill notation) is C7H7BF2O3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,6-Difluoro-4-methoxyphenylboronic acid with an assay of ≥95%. We do not represent this product as USP, BP, or EP grade.
How should 2,6-Difluoro-4-methoxyphenylboronic acid be handled?
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It is classified as a Warning substance (GHS07) causing skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Use a P261 dust mask (type N95), wear eyeshields and gloves. Ensure good ventilation.
Is 2,6-Difluoro-4-methoxyphenylboronic acid a controlled substance?
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The provided data does not indicate that 2,6-Difluoro-4-methoxyphenylboronic acid is a controlled substance.
How is this chemical shipped and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, handling the logistics for international delivery.
How can I request a quote or sample?
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Please contact our sales team directly through our website or official contact channels to request a quotation or a sample.
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