2,5-Dichlorobenzenesulfonyl chloride
2,5-Dichlorobenzenesulfonyl chloride (CAS: 5402-73-3) is an organic compound with the molecular formula Cl2C6H3SO2Cl and a molecular weight of 245.51 g/mol. This sulfonyl halide serves as a valuable building block in organic synthesis, particularly in the preparation of complex molecules. Its reactivity makes it suitable for research and development in the chemical and pharmaceutical industries.
- Synonyms
- Cl2C6H3SO2Cl

Synthesis of Benzoxazole Benzenesulfonamide Analogs
2,5-Dichlorobenzenesulfonyl chloride has been utilised in the study of synthesizing and understanding the structure-activity profiles of various benzoxazole benzenesulfonamide analogs. This research contributes to the development of new chemical entities with potential therapeutic applications.
Organic Synthesis Building Block
As a key intermediate, this compound is employed in the construction of more complex organic molecules. Its sulfonyl chloride group allows for facile derivatization, making it a versatile reagent in multistep synthetic pathways.
Pharmaceutical Intermediate Research
The compound's structure lends itself to applications in pharmaceutical research, where it can be incorporated into novel drug candidates or used to explore structure-activity relationships in medicinal chemistry.
| Molecular weight | 245.51 |
|---|---|
| Linear formula | Cl2C6H3SO2Cl |
| Assay | 98% |
| Application | 2,5-Dichlorobenzenesulfonyl chloride was used to study the synthesis and structure–activity profile of benzoxazole benzenesulfonamide analogs1. |
| Melting point | 36-37 °C(lit.) |


Hazard statements
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34-36/37 |
| Safety statements (S) | 26-27-28-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,5-Dichlorobenzenesulfonyl chloride used for?
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2,5-Dichlorobenzenesulfonyl chloride is primarily used as a building block in organic synthesis, including the preparation of benzoxazole benzenesulfonamide analogs and other complex organic molecules for research and pharmaceutical development.
What are the CAS number and formula for 2,5-Dichlorobenzenesulfonyl chloride?
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The CAS number for 2,5-Dichlorobenzenesulfonyl chloride is 5402-73-3, and its linear formula is Cl2C6H3SO2Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,5-Dichlorobenzenesulfonyl chloride with an assay of 98%. We do not represent this product as USP, BP, or EP grade.
What are the main safety hazards associated with 2,5-Dichlorobenzenesulfonyl chloride?
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This compound is classified as Danger, with hazard statements H314 (Causes severe skin burns and eye damage) and H335 (May cause respiratory irritation). Appropriate personal protective equipment, including eyeshields, faceshields, gloves, and suitable respiratory protection, must be used.
How is 2,5-Dichlorobenzenesulfonyl chloride packed, shipped, and exported?
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2,5-Dichlorobenzenesulfonyl chloride is packed in accordance with international transport regulations (UN 3261 8 / PGII). Tech Serve Solutions is an experienced global supplier and exporter of fine chemicals.
How can I request a sample or a quote for 2,5-Dichlorobenzenesulfonyl chloride?
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To request a sample or a quote, please contact our sales team directly through the Tech Serve Solutions website or by referencing product code 5402-73-3.
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