2,4-Dichlorophenylboronic acid
2,4-Dichlorophenylboronic acid (CAS 68716-47-2) is an organoboron compound with the formula Cl2C6H3B(OH)2 and a molecular weight of 190.82 g/mol. It is a key intermediate in organic synthesis, particularly recognised for its role in Suzuki coupling reactions. This disubstituted aryl boronic acid is also employed in the synthesis of various biologically active molecules, making it a valuable reagent in pharmaceutical research and development.
- IUPAC
- 2,4-Dichlorobenzeneboronic acid
- Synonyms
- 2,4-Dichlorobenzeneboronic acid
Suzuki Coupling Reactions
2,4-Dichlorophenylboronic acid serves as a crucial reactant in Suzuki coupling reactions, enabling the formation of new carbon-carbon bonds. It is effectively used with alkynyl bromides, anilines, and thiophenols to construct complex molecular architectures.
Synthesis of Biologically Active Molecules
This boronic acid is instrumental in synthesising molecules with significant biological activity. Notable applications include the preparation of N-hydroxyindole-2-carboxylates, which are investigated as lactate dehydrogenase inhibitors, and non-ATP competitive MK2 inhibitors.
Selective Hydroxylation
In organic chemistry, 2,4-Dichlorophenylboronic acid can be utilised for the selective hydroxylation of molecules, leading to the formation of phenol derivatives.
| Molecular weight | 190.82 |
|---|---|
| Linear formula | Cl2C6H3B(OH)2 |
| Application | Reactant involved in:• Suzuki coupling reactions with alkynyl bromides1,2 or aniline / thiophenol 3• Selective hydroxylation to phenols4Reactant involved in synthesis of biologically active molecules including:• N-hydroxyindole-2-carboxylates for use as lactate dehydrogenase inhibitors5• Non-ATP competitive MK2 inhibitors6 |
| Melting point | 246-249 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,4-Dichlorophenylboronic acid used for?
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2,4-Dichlorophenylboronic acid is primarily used as a reactant in Suzuki coupling reactions and for the synthesis of biologically active molecules, including lactate dehydrogenase inhibitors and MK2 inhibitors. It is also employed in selective hydroxylation processes.
What is the CAS number and chemical formula for 2,4-Dichlorophenylboronic acid?
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The CAS number for 2,4-Dichlorophenylboronic acid is 68716-47-2. Its linear formula is Cl2C6H3B(OH)2.
What grade and purity does Tech Serve Solutions supply for 2,4-Dichlorophenylboronic acid?
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Tech Serve Solutions supplies 2,4-Dichlorophenylboronic acid for research and chemical synthesis purposes. The specific assay and grade are available upon request, and it is not represented as USP, BP, or EP grade.
How should 2,4-Dichlorophenylboronic acid be handled safely?
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When handling 2,4-Dichlorophenylboronic acid, it is essential to wear appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used. Refer to the Safety Data Sheet for comprehensive handling and safety information. The compound has a melting point of 246-249 °C.
Is 2,4-Dichlorophenylboronic acid a controlled substance?
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The provided data does not indicate that 2,4-Dichlorophenylboronic acid is a controlled substance.
How is 2,4-Dichlorophenylboronic acid packed and shipped?
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2,4-Dichlorophenylboronic acid is carefully packed to ensure safe transit and is exported globally by Tech Serve Solutions. Packaging details and shipping options can be discussed when placing an order.
How can I request a quote or sample of 2,4-Dichlorophenylboronic acid?
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To request a quote or a sample of 2,4-Dichlorophenylboronic acid, please contact our sales team through the website or by phone. Our team will be happy to assist you with your inquiry.
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