2,4,6-Tri-tert-butylpyridine
2,4,6-Tri-tert-butylpyridine (CAS 20336-15-6) is a sterically hindered pyridine derivative with a molecular weight of 247.42. Its bulky tert-butyl groups provide significant steric hindrance around the nitrogen atom, influencing its reactivity and properties. This compound serves as a valuable building block in organic synthesis, particularly in reactions where a non-nucleophilic base or a sterically demanding ligand is required. It is frequently employed in chemical synthesis and research laboratories.
- Synonyms
- 20336-15-6C17H29N
Synthesis of Indole Triflones
2,4,6-Tri-tert-butylpyridine has been documented for its use in the synthesis of indole triflones. This application highlights its utility in constructing complex heterocyclic systems.
Sterically Hindered Base in Organic Reactions
Due to its significant steric bulk, this pyridine derivative can function as a non-nucleophilic base. This property is advantageous in organic reactions where it can scavenge protons without participating in nucleophilic side reactions.
Ligand in Organometallic Chemistry
The steric hindrance offered by the tert-butyl groups makes 2,4,6-Tri-tert-butylpyridine a potential ligand in organometallic chemistry, influencing the coordination environment around metal centres.
| Molecular weight | 247.42 |
|---|---|
| Empirical formula | C17H29N |
| Assay | 99% |
| Boiling point | 115-120 °C/20 mmHg(lit.) |
| Storage temperature | 2-8°C |
| Application | 2,4,6-Tri-tert-butylpyridine was used in the synthesis of indole triflones1. |
| Melting point | 67-71 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,4,6-Tri-tert-butylpyridine used for?
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2,4,6-Tri-tert-butylpyridine is primarily used as a building block in chemical synthesis, particularly in the preparation of indole triflones, and as a sterically hindered, non-nucleophilic base in various organic reactions.
What is the CAS number and molecular formula for 2,4,6-Tri-tert-butylpyridine?
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The CAS number for 2,4,6-Tri-tert-butylpyridine is 20336-15-6, and its empirical formula is C17H29N.
What grade and purity does Tech Serve Solutions supply for 2,4,6-Tri-tert-butylpyridine?
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Tech Serve Solutions supplies 2,4,6-Tri-tert-butylpyridine with an assay of 99%. This product is not represented as USP, BP, or EP grade.
How should 2,4,6-Tri-tert-butylpyridine be handled safely?
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2,4,6-Tri-tert-butylpyridine is a warning substance that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves, should be used. Handle in a well-ventilated area and avoid breathing dust.
Is 2,4,6-Tri-tert-butylpyridine a controlled substance?
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The provided data does not indicate that 2,4,6-Tri-tert-butylpyridine is a controlled substance.
How is 2,4,6-Tri-tert-butylpyridine packed and shipped?
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2,4,6-Tri-tert-butylpyridine is typically stored at 2-8°C. TSS, as a global supplier and exporter, ensures appropriate packaging and adherence to regulations for international shipments.
How can I request a quote or sample for 2,4,6-Tri-tert-butylpyridine?
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To request a quote or sample for 2,4,6-Tri-tert-butylpyridine, please contact our sales team through the website or by phone.
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