2,2′-Methylenebis[(4R,5S)-4,5-diphenyl-2-oxazoline]
2,2′-Methylenebis[(4R,5S)-4,5-diphenyl-2-oxazoline] (CAS: 139021-82-2) is a chiral ligand with the empirical formula C31H26N2O2 and a molecular weight of 458.55 g/mol. This C2 symmetric molecule is widely employed in asymmetric synthesis due to its ability to form stable bidentate coordination complexes with various metal centres, facilitating enantioselective catalysis.
- IUPAC
- (4R,5S,4′R,5′S)-2,2′-Methylenebis(4,5-diphenyl-2-oxazoline)
- Synonyms
- C31H26N2O2139021-82-2(4R,5S,4′R,5′S)-2,2′-Methylenebis(4,5-diphenyl-2-oxazoline)
![2,2′-Methylenebis[(4R,5S)-4,5-diphenyl-2-oxazoline] (5S)-4) — chemical structure, CAS 139021-82-2; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F139021-82-2.png&w=3840&q=75)
Asymmetric Catalysis
Utilised as a C2 symmetric ligand for enantioselective catalysis. Its nitrogen atoms readily form bidentate coordination complexes with transition metals, enabling stereoselective transformations in organic synthesis.
Chiral Ligand Synthesis
Serves as a valuable chiral building block for the construction of more complex catalytic systems. Its well-defined stereochemistry is crucial for inducing enantioselectivity in metal-catalyzed reactions.
Pharmaceutical Intermediate Synthesis
Finds application in the synthesis of chiral pharmaceutical intermediates where precise stereochemical control is paramount. The ligand's ability to influence reaction pathways aids in the efficient production of enantiomerically pure compounds.
| Molecular weight | 458.55 |
|---|---|
| Empirical formula | C31H26N2O2 |
| Assay | 99% |
| Application | C2 symmetric ligand for enantioselective catalysis. Easily forms bidentate coordination complexes due to the strong affinity of the oxazoline nitrogen for various metals.1,2,3 |
| Melting point | 205-208 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,2′-Methylenebis[(4R,5S)-4,5-diphenyl-2-oxazoline] used for?
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This compound is primarily used as a C2 symmetric chiral ligand in asymmetric synthesis and enantioselective catalysis. It readily forms bidentate coordination complexes with various metals.
What is the CAS number and chemical formula for 2,2′-Methylenebis[(4R,5S)-4,5-diphenyl-2-oxazoline]?
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The CAS number is 139021-82-2 and the empirical formula is C31H26N2O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with an assay of 99%. We do not represent it as USP, BP, EP or other pharmacopoeia grades.
How should 2,2′-Methylenebis[(4R,5S)-4,5-diphenyl-2-oxazoline] be handled?
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This compound is classified as a Warning. It may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment, including a dust mask (N95 type), eyeshields, and gloves. Ensure adequate ventilation.
Is this chemical packed and shipped internationally by TSS?
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Yes, Tech Serve Solutions specialises in global supply and export of fine chemicals, including this product.
How can I request a sample or obtain a quote?
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Please contact our sales team through the website to request a sample or to obtain a quotation for this product.
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