2,2′-Dithiobis(5-nitropyridine)
2,2′-Dithiobis(5-nitropyridine) (CAS: 2127-10-8), with the molecular formula C10H6N4O4S2 and a molecular weight of 310.31 g/mol, is a valuable reagent in organic synthesis. Its primary application involves the selective removal of the p-methoxybenzyl protecting group from cysteine and selenocysteine residues in peptide chemistry. This compound is supplied by Tech Serve Solutions with an assay of 96%.
- IUPAC
- Bis(5-nitro-2-pyridyl) disulfide,DTNP
- Synonyms
- Bis(5-nitro-2-pyridyl) disulfideDTNP
Protecting Group Removal
This reagent is specifically utilised for the cleavage of the p-methoxybenzyl (PMB) protecting group from the side chains of cysteine and selenocysteine amino acids. This is crucial in complex peptide synthesis to deprotect specific residues without affecting others.
Organic Synthesis Reagent
As a disulphide compound containing pyridine rings, it serves as a building block in various organic synthesis pathways. Its reactivity allows for targeted chemical modifications in the development of novel compounds.
Biochemical Research
In biochemical and medicinal chemistry research, 2,2′-Dithiobis(5-nitropyridine) aids in the controlled manipulation of peptides and proteins, facilitating studies on protein structure and function.
| Molecular weight | 310.31 |
|---|---|
| Empirical formula | C10H6N4O4S2 |
| Assay | 96% |
| Application | Reagent used to remove the p-methoxybenzyl protecting group from cysteine and selenocysteine side-chains.1 |
| Melting point | 155-157 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,2′-Dithiobis(5-nitropyridine) used for?
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2,2′-Dithiobis(5-nitropyridine) is primarily used as a reagent to remove the p-methoxybenzyl protecting group from cysteine and selenocysteine side-chains in chemical synthesis.
What is the CAS number and molecular formula for 2,2′-Dithiobis(5-nitropyridine)?
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The CAS number is 2127-10-8 and the molecular formula is C10H6N4O4S2.
What grade and purity does Tech Serve Solutions supply for 2,2′-Dithiobis(5-nitropyridine)?
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Tech Serve Solutions supplies 2,2′-Dithiobis(5-nitropyridine) with a minimum assay of 96%. TSS does not represent this product as USP, BP, EP or any other pharmacopoeia grade unless explicitly stated.
How should 2,2′-Dithiobis(5-nitropyridine) be handled safely?
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Based on its GHS classification, 2,2′-Dithiobis(5-nitropyridine) is a warning substance that can cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (type N95), eyeshields, and gloves, should be worn. Handle in a well-ventilated area.
Is 2,2′-Dithiobis(5-nitropyridine) a controlled substance?
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Based on the provided data, there is no indication that 2,2′-Dithiobis(5-nitropyridine) is a controlled substance.
How can I request a quote or sample for 2,2′-Dithiobis(5-nitropyridine)?
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To request a quote or sample of 2,2′-Dithiobis(5-nitropyridine), please contact the Tech Serve Solutions sales team via the website or direct inquiry channels.
Does Tech Serve Solutions export 2,2′-Dithiobis(5-nitropyridine)?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 2,2′-Dithiobis(5-nitropyridine).
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