4-Methylthiophene-2-carbonyl chloride
4-Methylthiophene-2-carbonyl chloride (CAS 32990-47-9) is a heterocyclic organic compound with the molecular formula C6H5ClOS and a molecular weight of 160.62 g/mol. This reactive acyl chloride, derived from thiophene, serves as a valuable building block in organic synthesis. It is particularly useful for introducing the 4-methylthiophene-2-carbonyl moiety into various molecular structures, finding application in the development of pharmaceuticals and fine chemicals.

Organic Synthesis Intermediate
Utilised as a key intermediate in the synthesis of complex organic molecules. Its reactive acyl chloride group readily participates in acylation reactions, enabling the formation of esters, amides, and other derivatives.
Pharmaceutical Research
Serves as a building block in the discovery and development of novel pharmaceutical agents. The thiophene core is present in various biologically active compounds.
Heterocyclic Chemistry
Employed in the construction of diverse heterocyclic systems. Its structure facilitates the incorporation of a substituted thiophene ring into larger molecular frameworks.
Material Science
Potentially used in the synthesis of functional materials where thiophene units can impart specific electronic or optical properties.
| Molecular weight | 160.62 |
|---|---|
| Empirical formula | C6H5ClOS |
| Assay | 97% |
| Density | 1.2873 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.581(lit.) |
| Storage temperature | 2-8°C |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Methylthiophene-2-carbonyl chloride used for?
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4-Methylthiophene-2-carbonyl chloride is primarily used as an intermediate in organic synthesis, particularly in the pharmaceutical and fine chemical industries for introducing the 4-methylthiophene-2-carbonyl group into target molecules.
What are the CAS number and formula for 4-Methylthiophene-2-carbonyl chloride?
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The CAS number is 32990-47-9 and the empirical formula (Hill notation) is C6H5ClOS.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Methylthiophene-2-carbonyl chloride with an assay of 97%. This product is intended for research and chemical synthesis purposes; TSS does not represent it as USP, BP, EP, or other pharmacopoeial grades.
How should 4-Methylthiophene-2-carbonyl chloride be handled?
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This compound is classified as corrosive (H314 - Causes severe skin burns and eye damage). Handling requires stringent safety precautions, including the use of appropriate personal protective equipment such as gloves, eye protection (eyesields, face shield), and respiratory protection (e.g., N100 or P3 filter respirator). Work should be conducted in a well-ventilated area or fume hood.
Is 4-Methylthiophene-2-carbonyl chloride a controlled substance?
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The provided data does not indicate that 4-Methylthiophene-2-carbonyl chloride is a controlled substance.
How is 4-Methylthiophene-2-carbonyl chloride packed and shipped?
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According to transport regulations (UN 3265, Class 8, PG II), this chemical is classified as a corrosive liquid, necessitating specific packaging and shipping protocols to ensure safe transit. TSS complies with all relevant international shipping regulations for hazardous materials.
How can I request a sample or quote?
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To request a sample or obtain a quotation for 4-Methylthiophene-2-carbonyl chloride, please contact our sales department via the website or direct email, specifying the quantity required and your delivery location.
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